中国药房2016，Vol.27Issue(24)：3320-3323,4.DOI:10.6039/j.issn.1001-0408.2016.24.02
我院万古霉素治疗药物监测横断面调查
Cross-sectional Survey on Therapeutic Drug Monitoring of Vancomycin in Our Hospital
郭冬杰 1李朋梅 1杜雯雯 1崔刚 1陈文倩 1张相林1
作者信息
摘要
Abstract
OBJECTIVE:To explore the necessity of developing therapeutic drug monitoring of vancomycin in our hospital and its existing problems,and provide a reasonable basis for the clinical rational use of vancomycin. METHODS:The cross-sectional survey was designed to collect the clinical data of 92 patients with therapeutic drug monitoring of vancomycin and statistically ana-lyze 192 cases of plasma concentration monitoring data. RESULTS:The average plasma trough concentration was (15.96 ± 8.06) mg/L;with the increase of age,the plasma trough concentration was increasing,there was no significant difference in the plasma trough concentration among different age groups (P=0.000);there were only 13 cases (6.77%) that obtained the plasma trough concentration within 30 min before the fourth dose;after using wancomycin,clearance rates of Cr and the endogenous creatinine were slightly higher than before,but there was no significant difference(P=0.722);36 cases(39.13%)showed vancomycin sus-ceptible gram positive cocci;after using wancomycin,the body temperature,white blood cell count and neutrophil percentage were lower than before,the differences were statistically significant (P=0.006,P=0.000,P=0.000);48 cases (52.17%) in treatment received initial loading dose,and only 15 cases (16.30%) did not use in combination with other anti infective drugs. CONCLU-SIONS:The results showed there are still a lot of problems in the treatment of vancomycin in our hospital,for example,the stan-dard rate of the plasma trough concentration is about 50%;most of the time of blood sampling is not reasonable;the detection rate of the pathogen is low;only about half of the cases are given the loading dose,etc. Therefore clinical pharmacists’intervention for blood sampling is an important part to promote rational drug therapy monitoring. Meanwhile,data interpretation of the monitoring results of serum drug concentration of vancomycin is a basic method for clinical pharmacists in clinical monitoring to correct the un-reasonable operations,and also the necessary measures for preventing the drug renal toxicity,it is a very important significance for the medication safety and effectiveness especially in severe infection patients,the elderly,the children and the people with renal function insufficiency.关键词
万古霉素/治疗药物监测/血药谷浓度/疗效/横断面调查Key words
Vancomycin/Herapeutic drug monitoring/Plasma trough concentration/Efficay/Cross-sectional survey分类
医药卫生引用本文复制引用
郭冬杰,李朋梅,杜雯雯,崔刚,陈文倩,张相林..我院万古霉素治疗药物监测横断面调查[J].中国药房,2016,27(24):3320-3323,4.
