中国药房2016，Vol.27Issue(24)：3340-3342,3.DOI:10.6039/j.issn.1001-0408.2016.24.08
注射用阿奇霉素致儿童不良反应危险因素分析
Analysis of Risk Factors of Adverse Reactions in Children Induced by Azithromycin for Injection
焦伟杰 1高天曙 1陈团营 1侯瑞英 1李雪静 1伏晓1
作者信息
- 1. 河南省中医院/河南中医药大学第二附属医院，郑州450002
- 折叠
摘要
Abstract
OBJECTIVE:To analyze the risk factors of adverse reaction in children induced by Azithromycin for injection. METHODS:Data and medication of 428 children used Azithromycin for injection were retrospectively collected,and logistic re-gression method was used to analyze the risk factors of adverse reactions that likely to occur. RESULTS:In the 428 children,98 re-ported adverse reactions with incidence of 22.9%,among which,53 showed gastrointestinal adverse reactions (12.4%),22 showed pain in injection site(5.1%),12 showed phlebitis(2.8%),4 showed pruritus(0.9%),2 showed rash(0.5%),3 showed liver function abnormalities(0.7%),1 showed thrombocytopenia(0.2%)and 1 showed drowsiness(0.2%). According to adverse reactions diagnostic criteria,24 were sure,23 were very likely and 51 were possible. Logistic regression analysis showed younger age [OR=0.811,95% CI(0.754,0.842),P=0.000] and long duration [OR=0.1.357,95% CI(1.212,1.519),P=0.000] might the rick factors that caused adverse reactions. CONCLUSIONS:Younger age and long duration are the possible rick factors that caused adverse reactions in children after intravenous administration of azithromycin,close observation and controlling duration should be noticed to reduce the incidence of adverse reactions in children medication.关键词
阿奇霉素/儿童/不良反应/危险因素Key words
Azithromycin/Children/Adverse reaction/Risk factor分类
医药卫生引用本文复制引用
焦伟杰,高天曙,陈团营,侯瑞英,李雪静,伏晓..注射用阿奇霉素致儿童不良反应危险因素分析[J].中国药房,2016,27(24):3340-3342,3.
