中国药理学通报2016，Vol.32Issue(9)：1194-1197,1198,5.DOI:10.3969/j.issn.1001-1978.2016.09.003
三氧化二砷心脏毒性研究进展
Research advances on cardiac toxicity of arsenic trioxide
摘要
Abstract
Arsenic trioxide has a significantly positive effect on the treatment of acute promyelocyte leukemia( APL) , and it also has been proved that arsenic trioxide can protect against some other kinds of malignant tumors in recent years. However, with the further research about arsenic trioxide, the reports about car-diac toxicity of arsenic trioxide are increasing. Currently, the possible mechanisms of As2 O3-induced cardiotoxicity are mainly considered to be associated with changes in cardiac ion chan-nels, oxidative stress injury and apoptosis. Research advances on cardiac toxicity of arsenic trioxide and some ways of preven-tion are summarized.关键词
三氧化二砷/急性早幼粒细胞白血病/心脏毒性/离子通道/氧化应激/凋亡Key words
arsenic trioxide/acute promyelocyte leukemia/car-diac toxicity/ion channels/oxidative stress/apoptosis分类
医药卫生引用本文复制引用
张静宜,孙桂波,王敏,孙晓波..三氧化二砷心脏毒性研究进展[J].中国药理学通报,2016,32(9):1194-1197,1198,5.基金项目
协和青年基金资助(No 3332015049) （No 3332015049）
中央高校基本科研业务费专项资金资助 （）
中医药行业专项基金( No 201507004) （ No 201507004）
