中国药理学通报2016，Vol.32Issue(9)：1203-1207,5.DOI:10.3969/j.issn.1001-1978.2016.09.005
氧化应激中ROS对FOXO3 a转录因子的调控作用研究进展
Redox regulation of FOXO3 a transcription factor
摘要
Abstract
ROS-mediated oxidative stress involved in a variety of cellular signal transduction, FOXO3a transcription factor is an intersection in regulating a variety of cellular oxidative stress. FoxO3a has been extensively studied in regulating oxidative stress because of its rather complex and pivotal regulation of cell proliferation, cell cycle arrest, ROS scavenging and apoptosis. This review will elucidate the FOXO3a’s regulatory mechanisms and describe the target genes involved. It will also provide the clinical significance and strategies to target FOXO3a to regulate oxidative stress.关键词
氧化应激/ROS/FOXO3a/调控作用/磷酸化作用/抗氧化酶Key words
oxidative stress/ROS/FOXO3a/regulation/phospho-rylation/antioxidant分类
医药卫生引用本文复制引用
李昂,邢雅琪,李晓霞,章吉威,郭会彩..氧化应激中ROS对FOXO3 a转录因子的调控作用研究进展[J].中国药理学通报,2016,32(9):1203-1207,5.基金项目
国家自然科学基金资助项目( No 81473292) （ No 81473292）
2016年河北省“大学生创新性实验计划”项目(No USIP2016020) （No USIP2016020）
