中国药理学通报2016，Vol.32Issue(9)：1306-1310,5.DOI:10.3969/j.issn.1001-1978.2016.09.023
香芹酚对STZ诱导的1型糖尿病小鼠糖脂代谢的影响
Effect of CAR on STZ-induced type 1 diabetic mice
摘要
Abstract
Aim Carvacrol ( CAR ) , possesses a wide variety of pharmacological properties including antioxi-dant and anti-inflammatory potential. The present stud-y is designed to investigate the effect of CAR on glu-cose and lipid metabolism in type 1 diabetic mice. Methods Diabetes was induced by intraperitoneal( i. p) injection of streptozotocin into male mice at the dose of 45 mg·kg-1 body weight( BW) . Mice were divided into three different groups containing eight to twelve in each. Age matched male C57 mice were used as nor-mal controls. Group I diabetes, Group Ⅱ and Ⅱ in-jected with CAR at 10 and 20 mg · kg-1 BW respec-tively once daily. After CAR injection 2, 4 or 6 weeks, the rats were weighted and the plasma concen-trations of glucose, total cholesterol( TC) , triglycerides (TG), Glutamic oxalacetic transaminase(AST), Ala-nine transaminase( ALT) levels were enzymatically de-termined using commercial kits. Results STZ-induced C57 BL/6 J diabetic mice showed an elevation in serum glucose, TG, ALT, AST and LDH levels. Compared to diabetic mice, administration of CAR resulted in sig-nificant decreases(P <0. 05) in plasma glucose, TG and LDH levels in a dose dependent manner, but no effect on elevated TC, ALT and AST levels. Conclu-sion These major findings provide evidence that CAR has anti diabetic property and it has the potential for development into a drug to prevent hyperglycemia, re-duce blood lipids and protect the dammaged organs.关键词
香芹酚/糖尿病/C57BL/6小鼠/STZ/糖脂代谢/腹腔注射Key words
CAR/diabetes/C57 BL/6 mice/STZ/glucose and lipid metabolism/intraperitoneal injection分类
医药卫生引用本文复制引用
麦云珮,张淑允,窦纪梁,张贵平,罗健东,侯宁..香芹酚对STZ诱导的1型糖尿病小鼠糖脂代谢的影响[J].中国药理学通报,2016,32(9):1306-1310,5.基金项目
国家自然科学基金项目( No 81402928) （ No 81402928）
广东省高等学校优秀青年教师培养计划( No YQ2015135) （ No YQ2015135）
广州市教育科研计划项目(No 2012C199) （No 2012C199）
