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食管癌变进程中间质成纤维细胞的表型变化

徐志彬 袁丽 郑秀丽 王士杰 吴明利

重庆医学2016,Vol.45Issue(27):3777-3779,3782,4.
重庆医学2016,Vol.45Issue(27):3777-3779,3782,4.DOI:10.3969/j.issn.1671-8348.2016.27.010

食管癌变进程中间质成纤维细胞的表型变化

Change of phenotype of stromal fibroblasts in esophageal carcinogenesis

徐志彬 1袁丽 1郑秀丽 1王士杰 1吴明利1

作者信息

  • 1. 河北医科大学第四医院内镜科,石家庄050011
  • 折叠

摘要

Abstract

Objective To investigate the expressions ofα‐SMA in different esophageal stromal fibroblasts in esophageal car‐cinogenesis .Methods IHC method was uesd to detect the expression of α‐SMA protein in stromal fibroblasts of twenty normal e‐sophageal tissues ,eighty precancerous lesions and fifty esophageal carcinomas respectively .Three kinds of esophageal stromal fibro‐blasts were cultured primarily and cells immunohistochemical staining was carrired out after being purified .Expression of α‐SMA was detected by RT PCR .Results IHC results showed thatα‐SMA expressions in normal ,precancerous and cancerous lesions were of significant differences .RT‐PCR results showed thatα‐SMA expressions were different significantly among three kinds of fibro‐blasts .Conclusion Esophageal stromal fibroblasts were activated with carcinogenensis .AFs was possibly the origion of CAFs .

关键词

食管肿瘤/间质细胞/间质成纤维细胞/癌变/表型

Key words

esophageal neoplasms/stromal cells/stromal fibroblast/carcinogenesis/phenotype

分类

医药卫生

引用本文复制引用

徐志彬,袁丽,郑秀丽,王士杰,吴明利..食管癌变进程中间质成纤维细胞的表型变化[J].重庆医学,2016,45(27):3777-3779,3782,4.

基金项目

河北省卫生厅医学科学研究重点课题计划(20160656)。 ()

重庆医学

OA北大核心

1671-8348

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