重庆医学2016，Vol.45Issue(27)：3788-3789,3792,3.DOI:10.3969/j.issn.1671-8348.2016.27.014
血清视黄醇结合蛋白联合脂联素对妊娠期糖尿病的早期预测价值
The value of combination of maternal retinol binding protein and adiponectin in predicting gestational diabetes mellitus
摘要
Abstract
Objective To detect the levels of retinol binding protein(RBP)and adiponectin during the second trimester in the serum of women in normal pregnancy and women who subsequently develop gestational diabetes mellitus(GDM )and to evaluate their role in predicting GDM .Methods A case‐control study was performed to detect and compare the levels of RBP and adiponec‐tin between women who subsequently develop GDM (n= 88)and normal control from 16 to 20 pregnancy weeks (n= 88) . Results Maternal serum RBP levels and the RBP/adiponectin ratio were significantly higher in GDM women than that in normal controls(P<0 .01) .The levels of maternal serum adiponectin were significantly lower in GDM women than that in normal controls (P<0 .01) .The levels of RBP≥30 .45 mg/L ,adiponectin≤9 .93 mg/L and the ratio of RBP/adiponetin≥3 .18 as early markers for predicating development of GDM ,their sensitivities were 63 .6% ,80 .7% and 81 .8% ,and specificities were 75 .0% ,65 .1% and 79 .7% ,respectively .Conclusion The combination of RBP and adiponetin as early marker for predicating development of GDM from 16 to 20 pregnancy weeks was more valuable than single use of them .关键词
视黄醇结合蛋白质类/脂联素/糖尿病 ,妊娠/预测Key words
retinol-binding proteins/adiponectin/diabetes ,gestational/forecasting分类
医药卫生引用本文复制引用
袁小松,张一鸣,蒋健,魏梓雯,周慧娜,蒋丽霞..血清视黄醇结合蛋白联合脂联素对妊娠期糖尿病的早期预测价值[J].重庆医学,2016,45(27):3788-3789,3792,3.基金项目
江苏省常州市科技规划项目（CJ20130041）。 （）
