动物营养学报2016，Vol.28Issue(9)：2673-2680,8.DOI:10.3969/j.issn.1006-267x.2016.09.002
氧化应激与自噬
Oxidative Stress and Autophagy
摘要
Abstract
Autophagy is a lysosome-dependent process aimed at degrading proteins and damaged organelles, in order to preserve cellular homeostasis and self-recycling in diverse conditions of stress. Oxidative stress, is a stress status when the balance of oxidation and anti-oxidation system breaks down, which subsequently cause cellular damage. A growing amount of evidence demonstrate that reactive oxygen species ( ROS) generated in oxidative stress is a main inducer of autophagy, and autophagy, in turn, serves to reduce oxidative damage and enhances cell survival. This article mainly described the process of autophagy, the mechanism of autophagy in-duction by oxidative stress and the pathway of antioxidant function mediated by autophagy. We attempt to pro-vide a theoretical basis of attenuating oxidative stress in livestock production through regulating autophagy.关键词
氧化应激/自噬/Atg/活性氧/氧化损伤Key words
oxidative stress/autophagy/Atg/ROS/oxidative damage分类
生物科学引用本文复制引用
吴艳萍,王阳,李雅丽,曹雪芳,李卫芬..氧化应激与自噬[J].动物营养学报,2016,28(9):2673-2680,8.基金项目
国家863计划项目(2013AA102800) （2013AA102800）
国家自然科学基金项目(31472128) （31472128）
