摘要
Abstract
Objective To explore the relationship between periodontitis and preeclampsia (PE) using Meta-analysis method. Methods The EMBASE, PubMed, CNKI, WanFang and CBM databases were searched up to Oct. 31, 2015, and the relevant references of the included studies were also retrieved manually. The literatures were screened accord-ing to the inclusion and exclusion criterias by 2 reviewers independently. The methodology quality was evaluated after data abstraction. RevMan 5.3 software was used for Meta-analyses. Results 13 studies consist of 12 case-control stud-ies and 1 cohort study were included. A total of 5 744 patients were involved, with 1 248 preeclampsia (PE) patients and 4 496 non PE patients. Meta-analysis showed that periodontitis increased the risk of PE with 2.67 times (OR =2.67, 95%CI=1.56-4.57, P<0.001). 3 subgroups of periodontitis were defined by pocket probing depth (PPD), clini-cal attachment level (CAL), and bleeding on probing (BOP), or by PPD with BOP, or by PPD. 3 subgroup analysis all re-vealed periodontitis was a risk factor, and the OR values were 2.91(95%CI=2.05-4.11, P<0.001), 2.33(95%CI=1.28-4.26, P=0.006) and 2.8 (95%CI=1.11-7.09, P=0.03) respectively. Sensitivity analysis showed the results was sta-ble and no publication bias was detected. Conclusion Periodontitis is a significant risk factor in PE according to this Meta analysis.关键词
牙周炎/先兆子痫/Meta分析/病例-对照研究/队列研究Key words
Periodontitis/Preeclampsia/Meta-analysis/Case-control study/Cohort study分类
医药卫生
