检验医学与临床2016，Vol.13Issue(19)：2749-2751,2754,4.DOI:10.3969/j.issn.1672-9455.2016.19.020
洛铂联合方案治疗晚期乳腺癌的临床研究
Clinical study of chemotherapy contains Lobaplatin in treating advanced breast cancer
摘要
Abstract
Objective To observe the efficacy and adverse reactions of chemotherapy regimens containing Lobaplatin in treat-ment of advanced breast cancer .Methods From January 2012 to December 2014 ,a total of 52 cases of advanced breast cancer were collected ,who accepted Lobaplatin-containing chemotherapy regimens ,21 - 28 days as a cycle .All patients completed at least two cycles and then the efficacy and adverse reactions were evaluated .Results No case obtained complete remission(CR) ,16 patients a-chieved part remission(PR) ,21 patients achieved stable disease(SD) ,15 patients achieved disease progression(PD) .The response rate was 30 .8% ,and the disease control rate was 71 .2% .There were no significant differences on the response rate among patients with negative and positive results of estrogen receptors(ER)and human epidermal growth factor receptor-2(HER-2)(P > 0 .05) . The significant difference was found on RR between the first-line treatment and second-line treatment (P < 0 .05) .Among triple negative breast cancer patients ,Stratification analysis by BRCA1 status ,there was significant difference of DCR between negative and positive BRCA1 patients(P < 0 .05) .The significant difference was found on RR between no visceral metastasis and visceral metastases patients(P< 0 .05) .Follow-up to the deadline ,the disease of 46 patients had progressed ,the median time of progression was 6 .5 months(95% CI :5 .2 - 7 .8 months) .The main side effects were myelosuppression ,gastrointestinal reactions ,which were mostly in degree 0 - Ⅱ ,and alleviated by symptomatic treatment .No treatment-related deaths occurred .Conclusion Lobaplatin-contained regimens has a significant antitumor effect to advanced breast cancer with manageable toxicities .关键词
乳腺癌/洛铂/联合化疗Key words
breast cancer/Lobaplatin/containing chemotherapy引用本文复制引用
张娜,刘美,曾晓华,辇伟奇..洛铂联合方案治疗晚期乳腺癌的临床研究[J].检验医学与临床,2016,13(19):2749-2751,2754,4.
