临床神经外科杂志2016，Vol.13Issue(5)：348-351,4.DOI:10.3969/j.issn.1672-7770.2016.05.008
神经外科术后颅内感染的危险因素及降钙素原等炎性标志物的诊断价值
Risk factors for postoperative intracranial neurosurgical infection and diagnostic value of ;inflammatory markers
摘要
Abstract
Objective To evaluate the risk factors for postoperative intracranial neurosurgical infection and explore the diagnostic value of serum and cerebrospinal fluid ( CSF ) marks for intracranial infection.Methods 321 patients were divided into two groups, infection group and no infection group.Risk factors predicating intracranial infection were collected as gender, age, site of tumor, duration of operation, blood transfusion and external ventricular drain.Serum and CSF procalcitonin ( PCT) , white blood cell ( WBC) counts, lactic acid ( LA) and glucose were detected and analyzed respectively.Results External ventricular drain was an independent risk factor for postoperative intracranial neurosurgery infection ( P =0.016).Serum and CSF LA, CSF WBC counts and CSF glucose could identify intracranial infection.However, there was no significant difference for serum and CSF PCT between the two groups.CSF glucose has a higher sensitivity (96.4%) and specificity (75.7%).Conclusion Serum and CSF LA, CSF WBC counts and CSF glucose could be proposed as effective diagnostic markers for postoperative intracranial neurosurgical infection.The diagnostic value of PCT wasn't detected in our study, further studies are needed to confirm the importance of PCT in diagnose intracranial infection.关键词
颅内感染/危险因素/血清和脑脊液/降钙素原/乳酸/白细胞计数/脑脊液糖Key words
intracranial infection/risk factors/serum and cerebrospinal fluid/procalcit-onin/lactic acid/white blood cell counts/glucose分类
医药卫生引用本文复制引用
郝京京,武元星,王强..神经外科术后颅内感染的危险因素及降钙素原等炎性标志物的诊断价值[J].临床神经外科杂志,2016,13(5):348-351,4.基金项目
2013年度首都医科大学基础临床科研合作课题（13JL24）；北京市科学技术委员会 （）
