摘要
Abstract
Objective Systematic evaluation on efficacy and safety of treatment in rheumatoid arthritis withetanercept and methotrexate compared with methotrexate alone. Methods Searches of Web of Science,Medline Embase,Cochrane Library,CBM, VIP,CJFDandWan Fang Database were all updated to Dec. 2015. Randomized controlled trials included were evaluated in methodo-logical quality according to the Cochrane systematic evaluation method with RevMan 5. 3 software for Meta analysis. Results Nine randomized controlled trials,1005 patients were included. Meta analysis results showed that,the curative effect of etanercept com-bined with methotrexate was superior to methotrexate alone group in the total effective rate,American College of Rheumatology RA remission ACR20,ACR50,ACR70,c-reactive protein(CRP),erythrocyte sedimentation rate(ESR),rheumatoid factor(RF),tender joint count(DAS28),rest pain(VAS),adverse drug reactions(ADR),etc. The difference was statistically significant(P<0. 05);In terms of ACR-N AUC and the incidence of ADR,the differences between the two groups had no statistical significance( P>0. 05). Conclusion The curative effect of etanercept combined with methotrexate is superior to methotrexate alone,but the quality of tests included is low,the conclusion also need high quality,large sample research for further validation.关键词
依那西普/甲氨蝶呤/类风湿关节炎/Meta分析Key words
etanercept/methotrexate/rheumatoidarthritis/meta-analysis分类
医药卫生
