四川医学2016，Vol.37Issue(10)：1149-1151,1152,4.DOI:10.16252/j.cnki.issn1004-0501-2016.10.024
神经纤维瘤病Ⅰ型合并双侧原发性乳腺癌1例报道及文献复习
A Case Report of Neurofibromatosis TypeⅠ Combined Bilateral Primary Breast Cancer and Literature Review
周庭庆 1万红芳1
作者信息
- 1. 绵阳市人民医院病理科，妇产科，四川 绵阳621000
- 折叠
摘要
Abstract
Objective To investigate the clinical features and pathological characteristics of neurofibromatosis type Ⅰconsolidation of bilateral metachronous primary breast cancer and improve diagnosis and treatment of such diseases. Methods Re-view of clinical data of one case of neurofibromatosis typeⅠconsolidation of bilateral metachronous primary breast cancer,and re-view of the literature,summarize and analyze such diseases related characteristics,treatment and prognosis. Results This NF1 pa-tient was diagnosed with right breast cancer( StageⅡB T2N1M) in our hospital in April 2014 for the first time,was treated with right breast excision,right axillary lymph node dissection,right axillary sentinel lymph node biopsy and right axillary fibrous tumor resection,4 courses of chemotherapy after operation and follow-up. The patient was diagnosed with left breast cancer ( StageⅣT2N2M1),was treated with left breast cancer palliative resection and chemotherapy after operation. This case of primary breast car-cinoma pathological types were both infiltrating ductal carcinoma;two breast carcinoma immunohistochemistry: Er (-) , PR (-) , HER-2( + +),HER2 over expression. The Ki-67 of primary right breast cancer was about 20%;and the Ki-67 of left breast canc-er later was about 70%. Conclusion Neurofibromatosis typeⅠconsolidation of bilateral metachronous primary breast cancer ca-ses are rare. Neurofibromatosis type Ⅰ increased risk of breast cancer. Molecular biological behavior of bilateral metachronous breast cancer on both sides of the primary lesion relevant,its relatively high degree of malignancy and poor prognosis.关键词
神经纤维瘤病Ⅰ型/双侧异时性原发性乳腺癌/乳腺浸润性导管癌/预后/预防Key words
neurofibromatosis typeⅰ/bilateral metachronous primary breast cancer/infiltrating ductal carcinoma/progno-sis/prevention分类
医药卫生引用本文复制引用
周庭庆,万红芳..神经纤维瘤病Ⅰ型合并双侧原发性乳腺癌1例报道及文献复习[J].四川医学,2016,37(10):1149-1151,1152,4.
