四川医学2016，Vol.37Issue(10)：1152-1156,5.DOI:10.16252/j.cnki.issn1004-0501-2016.10.025
早期应用替罗非班对急性冠脉综合征择期冠脉介入治疗心肌微循环灌注及左心室功能的影响
Effects of Tirofiban on Myocardium Ischemia-reperfusion and Left Ventricular Function of Patients with Acute Cor-onary Syndromes Undergoing Delayed Percutaneous Coronary Intervention
翁庆忠 1林文果 1刘丽 1何江 1肖祥彬1
作者信息
- 1. 宜宾市第二人民医院心内科，四川 宜宾644000
- 折叠
摘要
Abstract
Objective To explore the effects of platelet membrane glycoprotein GPllb/llla receptor antagonists tirofiban on myocardium ischemia-reperfusion and left ventricular function of patients with acute coronary syndromes( ACS) undergoing delayed percutaneous coronary intervention( delayed PCI) ,and to find out whether early administration of tirofiban in patients with ACS can improve myocardium ischemia – reperfusion before and after delayed PCI and left ventricular function at late stage and the prognosis of ACS. Methods 150 non-emergency hospitalized patients with ACS treated in our department of cardiology were selected and sim-ply randomized into observation group(tirofiban plus routine therapy,n=75)and control group(routine therapy only,n=75). All pa-tients were given coronary artery angiograph and PCI after one week. The degree of TIMI flow,corrected TIMI frame count( CTFC) af-ter PCI,left ventricular function indexes( NT pro BNP,LVEF,LVEDD,LVESD) and the incidence of bleeding complications examined before and 1,3,6,and 12 months after delayed PCI were compared and analyzed. Results The difference in the degree of TIMI flow of infarct-related artery(IRA)between two groups was not statistically significant(P>0. 05). CTFC of IRA after delayed PCI in the tirofiban therapy group was significantly lower than that in control group(P<0. 01). The difference in left ventricular function indexes (NT pro BNP,LVEF,LVEDD,LVESD)was also not statistically significant before and 1 months after delayed PCI(P>0. 05). Left ventricular function indexes in the tirofiban therapy group were significantly better than those in the control group 3 and 6 months after delayed PCI(P<0. 01). And the difference in the incidence of bleeding complications of two groups was not statistically significant (P>0. 05). Conclusions Early administration of tirofiban in patients with ACS undergoing delayed PCI improves myocardial reper-fusion and the prognosis of left ventricular function,without significant increase of the incidence of bleeding complications. Thus it helps patients with ACS who missed emergency revascularization to find a new treatment to improve the prognosis and provides refer-ence for clinical application.关键词
急性冠脉综合征/盐酸替罗非班/心功能/冠状动脉介入治疗/心肌微循环Key words
acute coronary syndrome/tirofiban/left ventricular function/percutaneous coronary intervention/myocardial reperfusion分类
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翁庆忠,林文果,刘丽,何江,肖祥彬..早期应用替罗非班对急性冠脉综合征择期冠脉介入治疗心肌微循环灌注及左心室功能的影响[J].四川医学,2016,37(10):1152-1156,5.
