生物加工过程2016，Vol.14Issue(5)：56-64,9.DOI:10.3969/j.issn.1672-3678.2016.05.011
戊己丸胃漂浮微丸制备工艺
Preparation of Wuji gastric-floating pellets
摘要
Abstract
We prepared the Wuji gastric-floating pellets and evaluated their characteristics in vitro.Carrier material of pellets was the sodium alginate, and the gastric-floating pellets were manufactured by ionic gelation. The influence of sodium alginate concentration, the ratio of sodium alginate and calcium carbonate, the ratio of sodium alginate and solid dispersion, calcium chloride concentration, acetic acid concentration and the ratio of Eudragit L100 and extracts were evaluated by single factor experiment. Central composite design/response surface method was used to optimize the formula, with the floating capacity of pellets as indicator.In the optimal formula,sodium alginate concentration was 20 g/L,the mass ratio of sodium alginate and calcium carbonate was 3. 5, the mass ratio of sodium alginate and solid dispersion was 2,calcium chloride concentration was 46 g/L,acetic acid concentration was 68 g/L,and the mass ratio of Eudragit L100 and extracts was 2. The optimal gastric-floating pellets can float for more than 10 hours and release the drug following the requirements of the sustained release formulation. The preparation condition was mild and process was simple, and the model established by response surface method showed good predictability.关键词
固体分散体/戊己丸胃漂浮微丸/离子凝胶法/星点设计效应面法Key words
solid dispersion/Wuji gastric-floating pellets/ionic gelation/central composite design/response surface method分类
医药卫生引用本文复制引用
张晓琳,张丹丹..戊己丸胃漂浮微丸制备工艺[J].生物加工过程,2016,14(5):56-64,9.基金项目
山东省高校科技计划 （）
