生物加工过程2016，Vol.14Issue(5)：65-69,5.DOI:10.3969/j.issn.1672-3678.2016.05.012
局部麻醉药盐酸达克罗宁高效合成工艺
Synthesis of local anesthetic dyclonine hydrochloride
摘要
Abstract
Dyclonine hydrochloride is commonly used as local anesthetics. We developed an efficient synthesis process of dyclonine hydrochloride, namely a novel two-step synthesis process. In this process, 4-hydroxyacetophenone and n-butyl bromide were used as the starting material, the intermediate 1-( 4-butoxyphenyl )-ethanone was produced by using the phase-transfer catalyst, and then dyclonine hydrochloride was obtained by further reacting with piperidinium chloride and paraformaldehyde. The structures of dyclonine hydrochloride were confirmed by 1 H-NMR and MS. The overall yield was more than 90%. It is an easy operation process and suitable for industrial production.关键词
盐酸达克罗宁/相转移催化剂/合成工艺Key words
dyclonine hydrochloride/phase-transfer catalyst/synthesis process分类
医药卫生引用本文复制引用
卢定强,严国荣,王新仙,吉文哲,刘桐岐,凌岫泉..局部麻醉药盐酸达克罗宁高效合成工艺[J].生物加工过程,2016,14(5):65-69,5.基金项目
国家自然科学基金 （）
