陕西医学杂志2016，Vol.45Issue(10)：1377-1379,3.DOI:10.3969/j.issn.1000-7377.2016.10.046
单纯疱疹病毒性角膜炎对角膜表层上皮细胞的影响
The morphologic features of corneal superficial epithelial cells and keratocytes in patients with herpes simplex keratitis
摘要
Abstract
Objective:To analyze the morphologic features of corneal superficial epithelial cells and ker‐atocytes by in vivo confocal microscopy in patients with herpes simplex keratitis (HSK) as associated with corneal innervation .Methods :We continued collecting 50 cases (100 eyes) with non acute period HSK who treated in our hospital and 50 healthy cases (100 eyes) at same time .Changes in morphologic features and density of the superficial epithelial cells ,were assessed by 2 masked observers .Changes were correlated to corneal sensation .Results:There was a significant decrease in the density of superficial epithelial cells 1287 .78 ± 102 .54 cells/mm2 in HSK eyes , 2425 .18 ± 202 .13 cells/mm2 in contralateral eyes and 2435 .23 ± 224 .3 cells/mm2 in normal eyes (P<0 .05) .Super‐ficial epithelial cell size was 2 .5‐fold larger in HSK eyes (606 .62 ± 198 .23 mm2 ) compared with contralateral (415 . 36 ± 58 .13 mm2 ) or normal eyes (409 .21 ± 63 .20mm2 ;P<0 .05) .Changes in superficial epithelial cell density(r=‐0 .90)and morphologic features (r = 0 .81)correlated strongly with corneal sensation(P<0 .05) .Conclusion:In vivo confocal microscopy reveals profound HSK‐induced changes in the superficial epithelium ,as demonstrated by increase in cell size ,decrease in cell density ,and squamous metaplasia .This study demonstrated that these changes correlate strongly with changes in corneal innervation .关键词
角膜炎 ,疱疹性/角膜/上皮细胞/显微镜检查 ,共焦Key words
Keratitis ,herpetic/Cornea/Epithelial cells/Microscopy ,confocal分类
医药卫生引用本文复制引用
王小东,程钰,李宏松,赵俊宏..单纯疱疹病毒性角膜炎对角膜表层上皮细胞的影响[J].陕西医学杂志,2016,45(10):1377-1379,3.基金项目
陕西省科学技术研究发展计划项目 （）
