天津中医药2016，Vol.33Issue(10)：592-595,4.DOI:10.11656/j.issn.1672-1519.2016.10.05
慢性心力衰竭患者血清和肽素水平与中医分型的相关性研究
Study on the relationship between the serum Copeptin level and the syndrome differentiation of traditional Chinese medicine in patients with chronic heart failure
摘要
Abstract
Objective] To evaluate the correlation between Copeptin which is the model marker of heart failure and syndrome differentiation of traditional Chinese medicine. [Methods] A prospective study was performed. Patients were consecutively collected 230 patients with coronary heart disease and hypertension admitted to department of cardiology were divided into three groups: NYHA II group (case 82), NYHA III group (case 76), NYHA IV group (case 72), and control group (case 51) with normal heart function. Combined with Guiding Principle of Clinical Research on New Drugs of Traditional Chinese Medicine and the common syndromes, 230 patients were divided into Heart-Qi-deficiency group (case 42), Qi-Yin deficiency group (case 64), Qi deficiency with syndrome of intermingled phlegm and blood stasis group (case 77), heart-kidney Yang deficiency group (case 47). Limosis vein blood sample of each patient was drawn in the morning. Serum concentrations of NT-proBNP, Copeptin and Estimation of left ventricular systolic function were detected. The serum Copeptin concentration and the serum NT-proBNP concentration were compared among all the groups. The relativity among the levels of NT-proBNP, the levels of Copeptin and NYHA classification were confirmed with linear correlation. [Results] The change of serum Copeptin and NT-proBNP were consistent in patients with heart failure. The serum NT-proBNP and Copeptin levels went up according to Heart- Qi - deficiency, Qi - Yin deficiency, Qi deficiency with syndrome of intermingled phlegm and blood stasis group, heart-kidney Yang deficiency in order. The Copeptin values was the highest in the heart-kidney yang deficiency group compared with Heart-Qi-deficiency group, Qi-Yin deficiency group and Qi deficiency with syndrome of intermingled phlegm and blood stasis group (pmol/L:27.40 (21.92,39.01), 18.80 (16.23,21.94), 14.19 (12.10,16.23), 8.93 (7.35,11.75), P<0.05. Heart-Qi deficiency and Qi-Yin deficiency were prevalent among patients of NYHA II, Qi deficiency with syndrome of intermingled phlegm and blood stasis were prevalent among patients of NYHAⅢ,heart-kidney Yang deficiency was prevalent among inpatients of NYHA IV. [Conclusion] The levels of serum NT-proBNP and Copeptin in patients with chronic heart failure may vary according to the severity of syndrome differentiation. It can provide the basis for the syndrome differentiation of traditional Chinese medicine and improve the accuracy of the syndrome differentiation.关键词
慢性心力衰竭/中医分型/和肽素/相关性Key words
heart failure/differentiation of traditional Chinese medicine/copeptin/correlation分类
医药卫生引用本文复制引用
刘玥,齐新,贾文军,魏丽萍,刘克强..慢性心力衰竭患者血清和肽素水平与中医分型的相关性研究[J].天津中医药,2016,33(10):592-595,4.基金项目
天津市中医药管理局基金资助项目（11100）。 （）
