天津中医药2016，Vol.33Issue(10)：604-609,6.DOI:10.11656/j.issn.1672-1519.2016.10.08
苦瓜-人参预防给药对高脂诱导肥胖小鼠胰岛素抵抗的影响
Effect of preventive administration of Momordica charantia-Panax ginseng herb on insulin resistance in high fat diet-induced obesity mice
摘要
Abstract
[Objective] To investigate the effects of preventive administration of Momordica charantia, Panax ginseng and Momordica Charantia-Panax ginseng herb on glucolipid metabolism and insulin resistance in high-fat diet induced obesity mice, and providing experimental evidence for the herb couple improving obesity and insulin resistance, therefore prevent T2DM. [Methods] Using insulin resistance model of high fat induced obesity mice, and fed Momordica charantia, ginseng, the herb couple respectively, with metformin as positive control. The food intake and body weight were measured every week. After 16 weeks drug intervention, the fat index, fasting plasma glucose (FPG), fasting insulin (FINS) and blood lipid were investigated; the level of insulin resistance was estimated by homeostasis model assessment for insulin resistance (HOMA-IR) and insulin sensitivity index (ISI);the level of regulating blood sugar was observed by oral glucose tolerance test (OGTT); histopathological changes of the adipose tissue were observed by HE staining. [Results] Ginseng can significantly improve insulin resistance. Momordica charantia can obviously reduce the FPG, weight and subcutaneous fat. The herb couple can obviously reduce the FINS and subcutaneous fat. Above intervention groups improved fat cells’ form of obese mice in different extent. [Conclusion] Ginseng can significantly improve insulin resistance in obesity mice, Momordica charantia can effectively reduce the FPG and weight, the herb couple have more advantages to reduce its FINS.关键词
苦瓜/人参/苦瓜 -人参对药/胰岛素抵抗/胰岛素敏感性/高脂诱导肥胖小鼠Key words
Momordica charantia/Panax ginseng/Momordica charantia-Panax ginseng herb couple/insulin resistance/insulin sensitivity/diet induced obesity mice分类
医药卫生引用本文复制引用
苏冷高娃,陈书,张耀丹,杨坤宝,白颖慧,鲁碧楠,庞宗然..苦瓜-人参预防给药对高脂诱导肥胖小鼠胰岛素抵抗的影响[J].天津中医药,2016,33(10):604-609,6.基金项目
国家自然科学基金项目（81273912）；国家自然科学基金青年基金项目（81302946）；教育部“长江学者和创新团队发展计划”（IRT_13R63）；中央民族大学博士研究生自主科研项目（Z2014035）。 （）
