物理学报2016，Vol.65Issue(17)：178701-0-178701-11,12.DOI:10.7498/aps.65.178701
蛋白质结构预测∗
Protein structure prediction
摘要
Abstract
Predicting 3D structure of proteins from the amino acid sequences is one of the most important unsolved problems in computational biology and biophysics. This review article attempts to introduce the most recent effort and progress on this problem. After a brief introduction of the background and basic concepts involved in protein structure prediction, we went through the specific steps that have been taken by most typical structural modeling approaches, including fold recognition, model initialization, conformational search, model selection, and atomic-level structure refinement. Several representative structure prediction methods were introduced in detail, including those from both template-based modeling and ab initio folding approaches. Finally, we overview the results shown in the community-wide Critical Assessment of protein Structure Prediction (CASP) experiments that have been developed for benchmarking the state of the art of the field.关键词
蛋白质结构预测/同源建模/从头预测/结构优化Key words
protein structure prediction/homology modeling/ab initio prediction/structure refinement引用本文复制引用
邓海游,贾亚,张阳..蛋白质结构预测∗[J].物理学报,2016,65(17):178701-0-178701-11,12.基金项目
国家自然科学基金(批准号:11547255,11474117)、中央高校基本科研业务费专项资金(批准号:2662015BQ045)和美国国立卫生研究院(批准号：GM083107, GM116960)资助的课题 （批准号:11547255,11474117）
