中国药业2016，Vol.25Issue(14)：29-31,3.
恩替卡韦与阿德福韦酯单药治疗对慢性乙型病毒性肝炎患者肾功能影响的比较
Effect Comparison of Entecavir and Adefovir as Monotherapy on Renal Function of Patients with Chronic Hepatitis B
摘要
Abstract
Objective To compare the effect of entecavir and adefovir administered as monotherapy on renal function of patients with chronic hepatitis B(CHB). Methods 100 patients diagnosised with CHB from 2014 to 2015 were selected and divided into two groups:group E(Entecavir,0. 5 mg∕d)and group A(Adefovir,10 mg∕d). The normalization of ALT,the undetectable rate of HBeAg or HBV DNA,the level of serum creatinine (Cr) and estimated glomerular filtration rate (eGFR) were compared from baseline period to post-treatment 52 weeks and 104 weeks. Results After treatment of 52 weeks and 104 weeks,the hepatitis B virus and anti-bio-chemical response of the two groups showed no significant difference ( P ﹥ 0. 05);there was no significant difference in the Cr and eGFR values between before treatment and after 52 weeks of treatment ( P ﹥ 0. 05);compared with before treatment,the Cr value of group A after 104 weeks was significantly higher( P ﹤ 0. 05),whereas the eGFR value was significantly lower( P ﹤ 0. 05);after 104 weeks,the Cr value of group A was significantly higher than group E ( P ﹤ 0. 05),and the eGFR value was significantly lower than group E( P ﹤ 0. 05). Conclusion Both entecavir and adefovir have similar efficacy in treating CHB,but adefovir may cause a certain degree of damaged on renal function.关键词
慢性乙型病毒性肝炎/恩替卡韦/阿德福韦酯/肾功能Key words
chronic hepatitis B/entecavir/adefovir/renal funtion分类
医药卫生引用本文复制引用
黄敬彬,刘德昭,黄树生..恩替卡韦与阿德福韦酯单药治疗对慢性乙型病毒性肝炎患者肾功能影响的比较[J].中国药业,2016,25(14):29-31,3.基金项目
广东省科技计划项目，项目编号2011B031800058。 （）
