中国药业2016，Vol.25Issue(14)：32-34,35,4.
加巴喷丁和氯胺酮用于子宫切除术后多模式镇痛效果比较
Comparison of Multimodal Analgesic Efficacy of Gabapentin and Ketamine in Hysterectomy
摘要
Abstract
Objective To compare the analgesic efficacy of gabapentin and ketamine for acute and chronic postoperative pains for pa-tients underwent hysterectomy. Methods 60 patients underwent hysterectomy were selected and randomly divided into ketamine group (group K)and gabapentin group(group G),30 cases in each group. In group K,patients were administered with 50 mg of victim C at the preoperative 2 h,then a loading dose of ketamine 0. 5 mg∕kg at the beginning of anesthesia,and a maintenance dose of ketamine at 0. 25 mg∕ ( kg·h ) during entire operation. In group G,patients were given gabapentin at a dose of 600 mg 2 h before operation,and 0. 9% sodium chloride with an equal volume of ketamine were injected as a loading dose and continuous infusion volume before and during operation. Two groups of patients were given remifentanil,propofol,cis atracurium induction and maintenance of anesthesia in order to achieve preemptive analgesia. The analgesia efficacy of the two groups were observed and compared. Results The VAS scores at the 0 h(in the PACU),and postoperative 0. 5,2,4,24 h in the group G were significantly less than those in the group K( P ﹤ 0. 05);the Ramsay scores at the 0 h(in the PACU),and postoperative 0. 5,2,4 h in the group G were significantly better than those in the group K( P ﹤ 0. 05);uses of sulfentanyl at the early postoperative time and times of pressing electronic pain control pump within post-operative 24 h in the group G were significantly less than those in the group K( P ﹤ 0. 05);the incidence rate of postoperative dizzi-ness,nausea,and vomiting showed no statistically significant differences between the two groups( P ﹥ 0. 05),additionally,restlessness in the group G was significantly less than that in the group K( P ﹤ 0. 05). Follow-up at the postoperative 2 month showed that VAS score in the group G were significantly less than that in the group K( P ﹤ 0. 05). Further follow-up at the postoperative 6 months found no statistically significant differences between the two groups( P ﹥ 0. 05). Conclusion In hysterectomy,gabapentin can provide more effective postoperative analgesia than ketamine at the commonly used doses. Furthermore,gabapentin can decrease postoperative con-sumption of opioid analgesics and reduce occurrences of chronic postoperative pain,which is worthy of clinical promotion.关键词
加巴喷丁/术后镇痛/子宫切除术/超前镇痛/慢性术后疼痛Key words
gabapentin/postoperative analgesia/hysterectomy/preemptive analgesia/chronic postoperative pain分类
医药卫生引用本文复制引用
金乐潇,董朝轩,卢园园,张冰,胡明品..加巴喷丁和氯胺酮用于子宫切除术后多模式镇痛效果比较[J].中国药业,2016,25(14):32-34,35,4.基金项目
浙江医学会临床科研资助项目，项目编号2012ZYC-A32。 （）
