摘要
Abstract
Objective To study the effect of dexmedetomidine on the circulation and inflammatory responses of patients with abdominal tumor radical prostatectomy. Methods 60 cases of patients with abdominal tumor radical prostatectomy from Jannuary 2015 to August 2015 were randomly divided into observation group and control group,30 cases in each group. Before anesthesia induction,the observa-tion group was given a small dose of dexmedetomidine 0. 5 μg∕kg,pumped in 10 min;the control group was given the same dose of 0. 9% NaCl injection,pumped in 10 min. The heart rate (HR),systolic blood pressure (SBP) and diastolic blood pressure(DBP)were monitored and recorded. During preoperative,intraoperative and postoperative,peripheral venous blood 3 mL was extracted respectively, using the ELISA method for determination of TNF-α,IL-6,IL-10 levels. At the same time,the occurrence rate of adverse reactions in both groups were observed. Results The perioperative SBP and DBP between the two groups had greater volatility,but volatility in the observation group was smaller than the control group( P ﹤ 0. 05). The heart rate at T1 and T2 of the two groups decreased signifi-cantly( P ﹤ 0. 05),when compared with T0,T1 and T2 represented a further decline( P ﹤ 0. 05),T3 showed a rebound,and the heart rates of the observation group at T1 and T2 were significantly lower than the control group ( P ﹤ 0. 05). At T1 and T2,the TNF-α, IL-10,IL-6 levels of the two groups increased significantly when compared with T0( P ﹤ 0. 05),T1 and T2 showed further increase when compared with T0( P ﹤ 0. 05). TNF-α,IL-10,IL-6 levels at T1 and T2 in the observation group were lower than the control group ( P ﹤ 0. 05). The two groups showed no obvious adverse reactions. Conclusion Peritoneal tumor resection prior to induction of anesthesia administered dexmedetomidine can effectively reduce the fluctuation of blood pressure patients and reduce inflammation,but can cause decreased heart rate,so the infusion rate cannot be too fast in order to improve perioperative safety.关键词
右美托咪定/腹腔肿瘤根治术/围术期/循环功能/炎性反应Key words
dexmedetomidine/abdominal tumor radical prostatectomy/perioperative period/circulation function/inflammatory response分类
医药卫生
