中国药业2016，Vol.25Issue(16)：27-29,30,4.
秦皮提取物及秦皮甲素对大鼠类风湿关节炎的保护作用
Protective Effects of Fraxini Cortex Extract and Aesculin on Rats with Rheumatoid Arthritis
摘要
Abstract
Objective To investigate the effect of fraxini cortex extract and aesculin on rheumatoid arthritis of rats and comPare the an-ti-inflammatory effect of fraxini cortex extract and aesculin. Methods Two model grouPs of arthritis rats induced by adjuvant which were similar to arthritis rheumatic and acute rats induced by carrageenan which were similar to acute arthritis were made and treated with fraxini cortex extract. The Paw thickness,weight changes were measured,and the joint score were recorded;the changes of IL-1β, TNF-α,MDA,and SOD in serum were detected by ELISA. Results ComPared with the blank grouP,the levels of IL-1β,TNF-α,and MDA in the two model grouPs were significantly increased,and the activity of SOD significantly reduced( P < 0. 05);the contents of IL-1β and TNF-α fraxini in the cortex extract and aesculin grouP were decreased significantly( P < 0. 05);the aesculin showed in-hibition effect on Proinflammatory after 1,2 h( P < 0. 05),fraxini cortex extract showed significant effect on SOD( P < 0. 05),and aes-culin showed better effect on reducing the level of TNF-α than fraxini cortex extract in the carageen model( P < 0. 05). In the adju-vant model,the MDA content decreased significantly in both grouPs( P < 0. 05),the aesculin grouP had lower joint score( P < 0. 05), and aesculin showed better effect on reducing the level of IL-1β than fraxini cortex extract( P < 0. 05). Conclusion Fraxini cortex extract and aesculin has certain theraPeutic effect on rheumatoid arthritis,and aesculin may be a major anti-inflammatory. Its mecha-nism may be associated with IL-1β and TNF-α levels.关键词
秦皮提取物/秦皮甲素/类风湿关节炎/角叉菜胶/弗氏完全佐剂Key words
fraxini cortex extract/aesculin/RA/carrageenan/freund′s comPlete adjuvant分类
医药卫生引用本文复制引用
汤丽芝,史亚军,刘继平,郭东艳,刘景楠..秦皮提取物及秦皮甲素对大鼠类风湿关节炎的保护作用[J].中国药业,2016,25(16):27-29,30,4.基金项目
国家中医药管理局中医药行业科研专题项目，项目编号201507002；陕西省中药制药重点学科资助项目，项目编号1999。 （）
