中国药业2016，Vol.25Issue(17)：1-4,5,5.
肾损害标志物在万古霉素治疗老年患者耐甲氧西林金黄色葡萄球菌血流感染中的应用价值
Renal Damage Markers in Vancomycin Treating Elderly Patients with MRSA Bloodstream Infection
摘要
Abstract
With the use of drugs, especially antibacterial drugs in clinical, the incidence rate of acute kidney injury induced by drugs ( DIAKI ) is increasing year by year. Vancomycin is the main drug for the treatment of bloodstream infections caused by Methicillin-resistant Staphylococcus aureus ( MRSA ) , and the main adverse drug reactions are renal toxicity. Because the concentration of vancomycin in the treatment range are close to the toxic concentration, and the individual difference is also varied, especially for the elderly whose renal reserve function, regulation mechanism and adaptive ability all attenuated, and is more prone to renal toxicity. Thus, early detection and early intervention are very important. This article reviews the status of vancomycin in the treatment of MRSA bloodstream infections and the pathogenesis of renal damage, and then discusses the clinical application value of a series of novel renal damage biomarkers in early renal damage.关键词
老年人/血流感染/万古霉素/肾损害标志物Key words
elderly/bloodstream infection/vancomycin/renal damage markers分类
医药卫生引用本文复制引用
李俊,陈媛媛,周甘平..肾损害标志物在万古霉素治疗老年患者耐甲氧西林金黄色葡萄球菌血流感染中的应用价值[J].中国药业,2016,25(17):1-4,5,5.基金项目
广西壮族自治区卫计委科研课题，项目编号Z2016240。 （）
