中国药业2016，Vol.25Issue(17)：31-34,35,5.
盐酸帕罗西汀缓释片的研制
Preparation of Paroxetine Hydrochloride Sustained-Release Tablets
胡献跃 1郑一美1
作者信息
- 1. 金华职业技术学院，浙江 金华 321007
- 折叠
摘要
Abstract
Objective To prepare the Paroxetine Hydrochloride Sustained-Release Tablets. Methods The HPMC of different specifica-tions was used as the blocking agent, the release characteristics of the self-made and SEROXAT reference tablets were compared in vitro, f2 was used to evaluate the similarity of the two dissolution curves, and the mechanism of the release behavior was fitted. Results The sustained-release tablets were made using HPMC E50 and K4M ( 1:1 ) as blocker, and the in vitro release behaviors were basi-cally the same with the reference tablets, the f2 was 77. 25. Both the release curve fitted the Korsmeyer-reppas equation. Conclusion The preparation method of Paroxetine Hydrochloride Sustained-Release Tablets is simple, and its dissolution behavior is highly similar to the reference tablets in the market.关键词
盐酸帕罗西汀/缓释片/羟丙基甲基纤维素/释放度/f2相似因子Key words
paroxetine hydrochloride/sustained-release tablets/HPMC/release rate/f2 similarity factor分类
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胡献跃,郑一美..盐酸帕罗西汀缓释片的研制[J].中国药业,2016,25(17):31-34,35,5.
