摘要
Abstract
Objective To study investigate the olanzapine and aripiprazole on chronic schizophrenia patients and glycolipid metabolism. Methods 175 cases of patients with chronic spirit schizophrenia from March 2014 to January 2016 in the hospital were selected and divided into two groups. The observation group ( 88 cases ) was treated with olanzapine, and the control group ( 87 cases ) was treated with aripiprazole. The glycolipid metabolism indicators, adverse reactions and treatment efficacy of the two groups after treatment were observed. Results The indexes of FBG, TC and TG in the observation group were all less than those in the control group, the differ-ence was statistically significant ( P ﹤ 0. 05 );the HDL-C and LDL-C indexes had no significantly difference compared with the con-trol group ( P ﹥ 0. 05 ); the incidence rate of adverse reactions in the observation group was 13. 64% ( 12/88 ) , which was less than 36. 78% ( 32/87 ) of the control group, the difference was statistically significant ( P ﹤ 0. 05 );the total effective rate in the observation group was 97. 73%, which was much better than 81. 61% in the control group, the difference was statistically significant ( P ﹤ 0. 05 ) . Conclusion Olanzapine in the treatment of chronic schizophrenia has more significant efficacy than aripiprazole, can reduce the incidence of complications, improve the therapeutic efficacy.关键词
奥氮平/阿立哌唑/慢性精神分裂症/疗效/糖脂代谢Key words
olanzapine/aripiprazole/chronic schizophrenia/efficacy/glycolipid metabolism分类
医药卫生
