摘要
Abstract
Objective To investigate the relationship between circulating vascular endothelial progenitor cells with vascular endothelial growth factor and cardiac function in patients with ST segment elevation of acute myocardial infarction. Methods 150 cases of patients with ST segment elevation of acute myocardial infarction in April 2012 to October 2014 in heart internal medicine department of the hospital were seleceted to collect the clinical data, and the vascular endothelial progenitor cells were detected using flow cytometry, vas-cular endothelial growth factor expression level was detected using enzyme-linked immunosorbent adsorption method, and its relationship with heart function was analyzed using Pearson correlation. Results Pearson correlation analysis showed that peripheral blood circulation vascular endothelial progenitor cells and serum VEGF levels were positively correlated with cardiac function ( r=0. 006 8, P=0. 001 ) . Circulating vascular endothelial progenitor cells and vascular endothelial growth factor in duration of 12 to 24 h were significantly high-er than that of course of ﹤12 h patients and difference was significantly significant difference ( P ﹤ 0. 05 );Vascular endothelial progeni-tor cells and vascular endothelial growth factor in course 24-48 h was significantly higher than that of course 14-24 h, the difference was significant ( P ﹤ 0. 05 ) . According to Killip classification, ST segment elevation acute myocardial infarction patients vascular endothe-lial progenitor cells and vascular endothelial growth factor level from low to high were as follows: grade Ⅳ ﹤ grade Ⅰ﹤ grade Ⅲ ﹤grade Ⅱ, the differences were statistically significant difference ( P ﹤ 0. 05 ) . Conclusion Circulating endothelial progenitor cells and serum vascular endothelial growth were positively correlated with ST segment elevation of acute myocardial infarction, cardiac insufficien-cy can reduce circulating endothelial progenitor cells and serum vascular endothelial growth of secretion and activation.关键词
冠状动脉粥样硬化性心脏病/急性心肌梗死/ST段抬高性/循环血管内皮祖细胞/血管内皮生长因子Key words
coronary heart disease/acute myocardial infarction/ST segment elevation/circulating vascular endothelial progenitor cells/vas-cular endothelial growth factor分类
医药卫生
