吉林大学学报（医学版）2016，Vol.42Issue(5)：954-957,4.DOI:10.13481/j.1671-587x.20160522
HIF-2α在非小细胞肺癌组织中的表达及其与微血管密度、Ki67和GST-π的关系
Expression of HIF-2αin non-small cell lung cancer tissue and its relationships with MVD,Ki67,and GST-π
摘要
Abstract
Objective:To investigate the expression of hypoxia-inducible factor-2α (HIF-2α)in non-small cell lung cancer (NSCLC)tissue,and to analyze its relationships with angiogenesis,cell proliferation and chemotherapy resistance. Methods: Total 112 cases of NSCLC and 20 cases of normal lung tissues were selected, immunohistochemical method was used to detect the expressions of HIF-2α,CD31,Ki67 and GST-π in 112 cases of cancer tissue and 20 cases of normal lung tissue,and the correlations of HIF-2α expression with microvessel density (MVD),Ki67, and GST-π were analyzed.Results:The positive expression rate of HIF-2α in NSCLC tissue was significantly higher than that in normal lung tissue (P < 0.05 ), the expression rate of HIF-2α in 112 cases of NSCLC was 47.3% (53/112).The MVD in HIF-2α protein high expression NSCLC group (31.1 ± 14.7)was higher than that in HIF-2αprotein low expression NSCLC group (24.3±15.8)(P <0.05).The cases of high expression of Ki67 in HIF-2αhigh expression group occupied 54.7% (29/53),and it was higher than that in HIF-2αlow expression group (16/59,27.1%);there was significant difference (r = 0.281,P = 0.003).The high expression of HIF-2α had no obvious correlation with the expression of GST-π (r = 0.122,P = 0.202). Conclusion:HIF-2αmay play an important role in the carcinogenesis and development of NSCLC by promoting the angiogenesis and enhancing the cell proliferation of NSCLC,but it may have no correlation with chemotherapy resistance.关键词
癌,非小细胞肺/缺氧诱导因子2α/血管生成/Ki67/GST-πKey words
cancer,non-small cell lung/hypoxia-inducible factor-2α/angiogenesis/Ki67/GST-π分类
医药卫生引用本文复制引用
云芬,贾永峰,韩昭,孙勤暖,李秀霞,于慧玲..HIF-2α在非小细胞肺癌组织中的表达及其与微血管密度、Ki67和GST-π的关系[J].吉林大学学报（医学版）,2016,42(5):954-957,4.基金项目
内蒙古自治区科技厅自然科学基金资助课题［2011MS1144，2015MS （LH）0807）］；内蒙古自治区科技厅应用技术研究与开发基金资助课题 （）
