吉林大学学报（医学版）2016，Vol.42Issue(5)：1014-1018,5.DOI:10.13481/j.1671-587x.20160535
指尖光学体积描记法检测血管内皮功能在冠心病患者筛查中的应用
Application of fingertip photoplethysmogram assessment of endothelial function in screening coronary heart disease patients
摘要
Abstract
Objective:To investigate the application of photoplethysmogram in analyzing the fingertip pulse amplitude volume (PAV)to evaluate the endothelial function in diagnosing coronary heart disease,and to clarify its relationship with the risk factors of cardiovascular diseases.Methods:Total 409 patients with chest pain accepted coronary angiography (CAG)were selected and diveded into positive group (CAG+)(n=288)and negative group (CAG-) (n = 121)according to angiographic results.Fingertip photoplethysmogram was used to analyze the fingertip PAV by the way of applying endothelial function diagnostic after reactive ischemia,and the relationship between the PAV value and the risk factors of coronary heart diseases was analyzed,and the critical reference value of prediction index of coronary heart disease was determined.The risk factors such as age,gender,serum total cholesterol (TC ), low density lipoprotein (LDL ), high density lipoprotein (HDL ), non-HDL, serum triglyceride (TG),hypertension,diabetes,smoking,family history of coronary heart disease,body mass index (BMI)of the subjects in various groups were analyzed,and the relationship between the risk factors of coronary heart disease and PAV was analyzed by Logistic regression analysis.Results:The PAV of patients in CAG+group was significantly lower than that in CAG-group (P <0.01).The peak point of PAV was<1.37,if PAV<1.37 was used to predict the coronary heart disease,the predictive sensitivity,the specificity,the positive prediction and the negative prediction were 74.65%,44.63%, 76.24%, and 42.52%.The Logistic regression analysis showed that PAV was negatively associated with hypertension,smoking history,TG (OR= 1.476,OR=2.002, OR = 1.844;P < 0.01 ). Conclusion: PAV is associated with coronary heart disease and its risk factors (hypertension,smoking history,TG),and PAV=1.37 can be used as the peak point to predict the coronary heart disease.关键词
指尖光学体积描记法/指尖脉搏容积/内皮依赖性血管舒张功能/冠状动脉粥样硬化性心脏病Key words
fingertip photoplethysmogram/pulse amplitude volume/endothelium-dependent vasodilation/coronary atherosclerotic heart disease分类
医药卫生引用本文复制引用
王云飞,司道远,杨萍..指尖光学体积描记法检测血管内皮功能在冠心病患者筛查中的应用[J].吉林大学学报（医学版）,2016,42(5):1014-1018,5.基金项目
吉林省科技厅科研基金资助课题（20140204016SF）；吉林省长春市科技局科研基金资助课题 （）
