磁共振成像2016，Vol.7Issue(9)：641-646,6.DOI:10.12015/issn.1674-8034.2016.09.001
MR氧摄取分数成像在星形细胞瘤分级的应用研究
The application of MR oxygen extraction fraction imaging in astrocytoma grading
摘要
Abstract
Objective:To explore the feasibility of quantitative measuring glioma oxygen extraction fraction (OEF) with OEF-imaging based on asymmetric spin-echo and to evaluate the diagnostic performance of OEF-related quantitative index in differentiating low- and high-grade gliomas.Materials and Methods: Thirty-two patients who were diagnosed with glioma via histopathology were recruited in the study, among which 16 cases were astrocytoma (gradeⅡ), 5 cases of anaplastic astrocytoma and 11 cases of glioblastoma. The informed consent forms were obtained before the patients received MR scanning and the protocol employs axial T1WI、T2WI、T2FLAIR、SE-DWI、T1WI+C and ASE-OEF. The OEF of solid part of tumor and contralateral white matter was manually measured by. The statistic analysis was based on independent-samplet-test andone-way ANOVA, to identify the manifestation and diagnostic performance in low- and high-grade gliomas, thePearson correlation analysis was applied to analyze the correlation between OEF and Ki-67 labeling index (Ki-67 LI).Results:In enhancement scanning, nonenhancement showed in ten of 16 low-grade gliomas, while only one patient showed nonenhancement, the difference of enhancement in low- and high-grade glioma was signiifcant (P=0.002). The OEF in high-grade glioma was signiifcantly higher than that in low-grade glioma (17.00±2.47 VS 20.46±2.98,P<0.01), the intra-class correlation coefifcient was 0.89 indicating a good consistency in measurement results. The difference of Ki-67 LI in gliomas was signiifcant (48±54.01,5.8±8.76,P=0.01) and the Ki-67 LI was mildly correlated with OEF (r=0.406,P<0.05). The AUC of qualitative index depending on enhancement or nonenhancement in tumor solid part was 0.781 with 93.8% sensitivity and 62.5% speciifcity, while the AUC of OEF in differentiating low-and high-grade gliomas was 0.852 at a best threshold value of 19.55 with 81.3% sensitivity and 87.5% speciifcity.Conclusions:The ASE-MRI based on EPI can be applied in non-invasive measurement of glioma OEF. The quantitative parameter OEF is a excellent biomarker in differentiating high- and low-grade gliomas with good diagnstic performance and partly relfects the tumor proliferations. The potential application value of OEF in the diagnosis and management of glioma is worthwhile.关键词
氧摄取分数成像/磁共振成像/神经胶质瘤/肿瘤分级Key words
Oxygen extraction fraction imaging/Magnetic resonance imaging/Glioma/Neoplasm grading分类
医药卫生引用本文复制引用
苏昌亮,朱文珍,张佳旋,张顺,江晶晶,蒋日烽,刘城霞,张巨,林晖,赵凌云..MR氧摄取分数成像在星形细胞瘤分级的应用研究[J].磁共振成像,2016,7(9):641-646,6.基金项目
国家自然科学基金(编号8157021103、81171308)；国家十二五支撑计划(编号2011BAI08B10)ACKNOWLEDGMENTS National "Twelfth Five-Year" Program of Science & Technology Support (No.2011BAI081310). National Natural Science Foundation of China (No.8157021103,81171308) （编号8157021103、81171308）
