摘要
Abstract
Objective To explore the influence of Helicobacter pylori eradication on the serum level of COX-2 in patients with Helicobacter pylori related gastric disease.Methods 310 patients with Helicobacter pylori related gastric disease treated at our hospital from July,2014 to January,2016 were divided into a gastric ulcer group (117 cases),a duodenal ulcer group (96 cases),and a chronic atrophic gastritis group (97 cases) according to the pathological diagnosis results.60 healthy people were selected as a control group.All the Hpinfected patients underwent standard quadruple therapy.The Hp eradication rates were recorded.The ulnar vein blood was extracted from all the objects.The serum levels of Cyclooxygenase-2 in the four groups were detected by enzyme-linked immunosorbent assay method.Results Among the 310 gastric disease patients,273 cases' HP were eradicated,with an Hp eradication rate of 88.1％ (273/310).The HP eradication rate in the gastric ulcer group was not statistically different from that in the duodenal ulcer group (x 2=2.375,P＜0.05).The HP eradication rate was significantly higher in the gastric ulcer group and the duodenal ulcer group than in the chronic atrophic gastritis group (x 2=3.996,9.162,P＜0.05).The serum level of COX-2 was significantly higher in the gastric ulcer group,the duodenal ulcer group,and the chronic atrophy gastritis group than in the control group (P＜0.05).The serum level of COX-2 was significantly higher in the gastric ulcer group and the duodenal ulcer group than in the chronic atrophic gastritis group (P＜0.05).The was no statistical difference in the serum level of COX-2 between the gastric ulcer group and the duodenal ulcer group (P＞0.05).The serum level of COX-2 was significantly higher after than before successful HP eradication in the gastric ulcer group,the duodenal ulcer group,and the chronic atrophic gastritis group (P＜0.05).There were no statistical differences in the serum level of COX-2 between before and after failure HP eradication in the gastric ulcer group,the duodenal ulcer group,and the chronic atrophic gastritis group (P＞0.05).Conclusions After the successful eradication of Hp in patients with Hp related gastric disease,the serum level of COX-2 decrease significantly.The serum level of COX-2 can be used as one of the Hp eradication efficacy evaluation indicators.关键词
幽门螺旋杆菌/胃病/环氧合酶-2/疗效指标Key words
Helicobacter pylori/Gastric disease/Cyclooxygenase-2/Therapeutic indicators
