摘要
Abstract
Objective To compare the number of embryo between cleavage stage embryos transfer and blastocyst transfer so as to look for the strategies to reduce the rate of multiple-pregnancies.Methods The patients, undergoing in vitro fertilization /intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) in Reproductive Center of Northwest Women and Children's Hospital during January 1, 2014 to June 30, 2015 were enrolled as research objects.The cleavage stage group included cases with fresh or thawed embryos transferred at the third day.The blastocyst stage group included the cases with fresh and thawed embryos transferred at the fifth day.According to the number of embryos transferred (1-3), two groups were compared in clinical pregnancy and multiple-pregnancy rate.Results A total of 7 454 cycles were transferred, including 4 756 fresh cycles and 2 698 cycles of frozen thawed embryo transfer.When the number of transfer was same, the clinical pregnancy rate of blastocyst transfer was significantly higher than that of cleavage stage embryos transfer ( P value was 0.001.0.001 and 0.033, respectively, for 1, 2 and 3 embryo transfer).When the number of cleavage stage embryos increased from 2 to 3, the clinical pregnancy rate was not increased but decreased (P=0.002), while no significant difference was found in multiple-pregnancy rate ( P =0.252).Therefore, transferring 3 cleavage embryos did not improve the clinical pregnancy rate and multiple-pregnancy rate did not change a lot.To increase the number of embryos transferred in blastocyst group from 2 to 3, the clinical pregnancy rate increased slightly (P=0.739) and multiple-pregnancy rate increased (P=0.595) without significant difference.Conclusion When the number of cleavage stage embryo transferred increases from 1 to 3, clinical pregnancy rate can be maintained without increasing of risk of multiple-pregnancy rate by increasing the number of transferred embryos.To increase the number of embryos transferred in blastocyst group, the clinical pregnancy rate is not significantly improved, but the risk of multiple-pregnancy rate increases.Therefore, the recommended number of blastocyst transferred is 1-2, and 3 blastocyst is forbidden to transfer.关键词
体外受精胚胎移植(IVF-ET)/卵裂期胚胎/囊胚/移植胚胎数目Key words
in vitro fertilization-embryo transfer(IVF-ET)/cleavage stage embryo/blastocyst/number of embryos transferred分类
医药卫生
