中国妇幼健康研究2016，Vol.27Issue(9)：1114-1116,3.DOI:10.3969/j.issn.1673-5293.2016.09.028
小儿肠道外感染性疾病应用抗生素后肠道菌群失调的临床分析
Clinical analysis of enteric flora imbalance after antibiotics use for parenteral infection diseases among infants
摘要
Abstract
Objective To investigate the influence of antibiotics application for parenteral infection on intestinal flora.Methods A retrospective analysis was conducted on 149 cases of children treated in Baoji Maternity and Child Health Hospital for parenteral infection during the period of January 2013 to August 2014.The bacteriological analysis was carried out on feces of children before using antibiotics and 1d, 3d, 7d and 14d after using them, and they were compared to those of healthy children selected in the same period.The difference in intestinal flora and the proportion of enteric flora imbalance were analyzed.Results The proportion of children suffering enteric flora imbalance after use of antibiotics for parenteral infection was 64.43%, and they wereⅠandⅡdegree of enteric flora imbalance.No case was found with dysbacteriosis of Ⅲ degree.The proportion of cases with enteric flora imbalance was highest in infant group, and the difference was statistically significant (χ2 =8.89, P<0.05).The differences in main composition of flora between cases of enteric flora imbalance and healthy cases were statistically significant (χ2 =102.73, both P<0.01).Conclusion For children, especially infants, narrow spectrum antibiotics should be given as far as possible, and the duration of antibiotics use should be shortened to protect the normal intestinal flora.关键词
小儿/非肠道感染性疾病/抗生素/肠道菌群失调Key words
infants/parenteral infection diseases/antibiotics/enteric flora imbalance分类
医药卫生引用本文复制引用
王玉瑛,张孝兴,汤淑斌,焦爱萍,高怡玢,庞伟斌,刘莹..小儿肠道外感染性疾病应用抗生素后肠道菌群失调的临床分析[J].中国妇幼健康研究,2016,27(9):1114-1116,3.基金项目
宝鸡市卫生局科研立项资助项目 （）
