检验医学与临床2016，Vol.13Issue(18)：2576-2578,2581,4.DOI:10.3969/j.issn.1672-9455.2016.18.009
Reprimo 基因3′非翻译区824位点多态性与肺癌发病的相关性研究
The correlation between Reprimo 824 polymorphism and lung cancer
摘要
Abstract
Objective To investigate the relationship between Reprimo gene 3′‐untranslated region 824 G > C polymorphism and lung cancer .Methods Genotyping was performed by using MightyAmp DNA Polymerase ,36 lung cancer patients(cancer group) and 23 lung cancer patients(control group) were genotyped .The results of investigation were analyzed with χ2 test ,Logistic regres‐sion and Armitage′s trend test .Results According to Hardy‐Weinberg equilibrium examination ,the observed frequencies of GG , GC and CC in Reprimo 824 G > C genotype of control group were 21 ,1 and 1 ,respectively ,while the theoretical frequency were 20 .01 ,2 .80 and 0 .10 respectively(no statistically significant difference was observed ,P= 0 .067) .The observed frequencies of GG , GC and CC in Reprimo 824 G > C genotype of cancer group were 33 ,1 and 2 ,respectively ,while the theoretical frequency were 31 .17 ,4 .65 and 0 .17 ,respectively(no statistically significant difference was observed ,P= 0 .067) .Tested by using Logistic regres‐sion ,gene polymorphism ,age ,smoking status and lung cancer(P> 0 .05) .Armitage′s trend test revealed no statistically significant correlation between Reprimo 824 G > C polymorphism and susceptibility to lung cancer (χ2 = 0 .00 ,P = 0 .946) .Conclusion This study indicates that there is not an association between the Reprimo gene 3′‐untranslated region 824 G > C polymorphism and lung cancer .关键词
肺癌/Reprimo 基因/多态性/哈迪-温伯格平衡Key words
lung cancer/Reprimo gene/polymorphism/Hardy-Weinberg equilibrium引用本文复制引用
陈贤华,刘和艳,詹前美,徐玉婵,刘大鹰..Reprimo 基因3′非翻译区824位点多态性与肺癌发病的相关性研究[J].检验医学与临床,2016,13(18):2576-2578,2581,4.基金项目
广西壮族自治区卫生厅计划课题（Z2010138）；广西壮族自治区柳州市科学技术局技术研究与开发计划课题（2011J0302031）。 （）
