检验医学与临床2016，Vol.13Issue(18)：2579-2581,3.DOI:10.3969/j.issn.1672-9455.2016.18.010
血清癌胚抗原与溶血磷脂酸联合检测在非小细胞肺癌诊断中的应用价值
The value of serum carcinoembryonic antigen combined with lysophosphatidic acid detection in the diagnosis of non-small cell lung cancer
曹青梅1
作者信息
- 1. 延安大学附属医院检验科，陕西延安 716000
- 折叠
摘要
Abstract
Objective To investigate the value of serum carcinoembryonic antigen(CEA) combined with lysophosphatidic acid (LPA) detection in the diagnosis of non‐small cell lung cancer .Methods From January 2013 to June 2015 ,85 cases of non‐small cell lung cancer patients in the hospital were enrolled in the study as non‐small cell lung cancer group .In addition to that ,80 cases of patients with pneumonia and 80 cases of healthy people were recruited as pneumonia and control group respectively .LPA and CEA concentrations of those people were determined by using enzyme‐linked immunosorbent assay and immunoluminescence meth‐od .Serum CEA and LPD concentrations among different groups and positive rate of serum markers among patients with non small cell lung cancer of different pathological types were compared .Efficacies of single and combined detection of CEA and LPA in the diagnosis of non small cell lung cancer were also compared .Results Serum CEA and LPA concentrations of patients with non‐small cell lung cancer were (23 .5 ± 17 .2)ng/mL and (9 .8 ± 2 .4)μmol/L respectively ,which were both significantly higher than pneumo‐nia group[(2 .8 ± 1 .1)ng/mL and (1 .8 ± 0 .4)μmol/L] and control group[(2 .3 ± 0 .8)ng/mL and (1 .6 ± 0 .4)μmol/L)] ,and the difference was statistically significant(P< 0 .05) .Serum CEA positive rate of adenocarcinoma cancer patients(68 .3% ) was signifi‐cantly higher than patients with squamous cell carcinoma(32 .4% ) and no tissue type (40 .4% ) ,the difference was statistically sig‐nificant(P< 0 .05) .Detection accuracy(69 .4% ) and sensitivity(61 .2% ) of serum carcinoembryonic antigen combined with lyso‐phosphatidic acid was higher than the single detection while specificity (73 .8% ) was less than single detection of CEA and LPA (77 .5% and 75 .6% ) .Conclusion Serum carcinoembryonic antigen combined with lysophosphatidic acid detection help to improve the rate of non‐small cell lung cancer ,and it was worthy of clinical application .关键词
血清癌胚抗原/溶血磷脂酸/非小细胞肺癌Key words
serum carcinoembryonic antigen/lysophosphatidicacid/non-small cell lung cancer引用本文复制引用
曹青梅..血清癌胚抗原与溶血磷脂酸联合检测在非小细胞肺癌诊断中的应用价值[J].检验医学与临床,2016,13(18):2579-2581,3.
