检验医学与临床2016，Vol.13Issue(18)：2602-2603,2606,3.DOI:10.3969/j.issn.1672-9455.2016.18.018
腔隙性脑梗死患者血浆同型半胱氨酸和血脂水平检测的意义
Significance of plasma homocysteine and lipids level detection in patients with lacunar cerebral infarction
贺嘉蕾 1唐大海 1朱月星 1韩雪颖1
作者信息
- 1. 中国人民解放军第四一一医院检验科，上海 200083
- 折叠
摘要
Abstract
Objective To study the relationship between the lacunar cerebral infarction (LS) and plasma homocysteine (Hcy) and lipids levels .Methods The plasma Hcy ,total cholesterin(TC) ,triglyceride(TG) ,high density lipoprotein cholesterol(HDL‐C) ,low density lipoprotein cholesterol(LDL‐C) ,apolipoprotein A1(ApoA1) ,apolipoprotein B(ApoB) and Lp(a) levels in 99 pa‐tients with LS and 242 controls were measured by the automatic biochemical analyzer .Then the principle component analysis (PCA) and Logistic regression analysis were performed .Results The proportions of smoking ,hypertension and diabetes and the plasma Hcy ,TC ,TG ,ApoB and Lp(a) levels in the LS patients were significantly higher than those in the control group (P <0 .05) ,and the plasma ApoA1 level was significantly lower than that in the control group (P< 0 .05) .The PCA model revealed that there were obvious disorders of plasma Hcy level and blood lipids metabolism in the patients with LS and a separation tendency from the control group .The Logistic regression model could accurately predict 82 .8% of LS patients and 95 .9% of controls ,and revealed that the odds ratio (OR) of hypertension and plasma Hcy level was 8 .45(P< 0 .05) and 2 .47(P< 0 .05) respectively .Con‐clusion Hypertension and the increase of plasma Hcy level are the independent risk factors of LS .The regression models of PCA and Logistic based on level of plasma Hcy and lipids are helpful for the assisted diagnosis and prediction of LS .关键词
腔隙性脑梗死/腔隙性卒中/同型半胱氨酸/血浆Key words
lacunar cerebral infarction/lacunar stroke/homocysteine/plasma引用本文复制引用
贺嘉蕾,唐大海,朱月星,韩雪颖..腔隙性脑梗死患者血浆同型半胱氨酸和血脂水平检测的意义[J].检验医学与临床,2016,13(18):2602-2603,2606,3.
