检验医学与临床2016，Vol.13Issue(18)：2619-2621,3.DOI:10.3969/j.issn.1672-9455.2016.18.024
哮喘和慢性阻塞性肺疾病重叠综合征患者血清维生素D水平改变及其临床意义
Change and clinical significance of serum vitamin D level in patients with asthma-COPD overlap syndrome
王丽峰 1张春芳1
作者信息
- 1. 陕西省西安高新医院呼吸内科 710061
- 折叠
摘要
Abstract
Objective To investigate the change and clinical significance of serum vitamin D level patients with asthma‐chronic obstructive pulmonary disease(COPD) overlap syndrome (ACOS) .Methods Consecutive 22 cases of asthma ,32 cases of COPD and 26 cases of ACOS were enrolled in this study .The pulmonary function situation and difference of serum vitamin D levels were compared and analyzed among these three groups .Results The FEV1 improvement value after inhaling bronchodilators in the asth‐ma group and ACOS group was significantly higher than that in the COPD group(0 .46 ± 0 .14L ,0 .37 ± 0 .08L vs .0 .23 ± 0 .08L , P< 0 .05) .The FEV1% pred level in the COPD and ACOS group was significantly lower than that in the asthma group(P< 0 .05) . The serum 25(OH)D3 level in the COPD group was significantly lower than that in the asthma group and ACOS group ,while the asthma group was significantly higher than the ACOS group(P< 0 .05) .The serum vitamin D level in these three groups was nega‐tively correlated with the smoking index (asthma group :r = - 0 .582 ,P = 0 .029 ;COPD group :r = - 0 .601 ,P = 0 .022 ;ACOS group :r= - 0 .687 ,P= 0 .015) .The serum vitamin D level in the ACOS group was positively correlated with the FEV1 improve‐ment value and FEV1% pred (r= 0 .620 ,P= 0 .032 ;r= 0 .489 ,P= 0 .037) .The area under the roc curve(AUC) of serum vitamin D level for diagnosing ACOS was 0 .643(95% CI 0 .523 - 0 .678) .Conclusion The serum vitamin D level in ACOS patients is lower than that in asthmatic patients ,but higher than that in COPD patients ,moreover which has a certain correlation with pulmonary function .关键词
哮喘/慢性阻塞性肺疾病/血清维生素D水平/临床意义Key words
asthma/COPD overlap syndrome/serum vitamin D level/clinical significance引用本文复制引用
王丽峰,张春芳..哮喘和慢性阻塞性肺疾病重叠综合征患者血清维生素D水平改变及其临床意义[J].检验医学与临床,2016,13(18):2619-2621,3.
