摘要
Abstract
Objective To investigate the incidence ,risk factors and clinical features of bronchopulmonary dysplasia (BPD) a‐mong very low birth weight infants .Methods Very low birth weight infants admitted to our hospital from September 2011 to De‐cember 2014 .BPD were taken as the research subjects and grouped according whether BPD occurring and severity .The retrospec‐tive analysis was performed .Results The BPD occurrence rate in very low birth weight infants was 17 .5% .The gestational age , birth weight ,Apgar score in the BPD group were lower than those in the non‐BPD group ,and the hospitalization duration in the BPD group was significantly prolonged (P< 0 .05) .The gestational hypertension ,neonatal respiratory distress syndrome (NRDS) , sputum culture positive ,pulmonary hemorrhage ,apnea ,respiratory failure and sepsis incidence had statistical difference between the two groups(P< 0 .05) ;the use rates of pulmonary surfactant(PS) ,oxygen therapy and mechanical ventilation in the BPD group were significantly higher than those in the non‐BPD group(P< 0 .05) .The Logistic regression analysis revealed that the gestational age(GA) (OR = 0 .474 ,P= 0 .004) and NRDS (OR = 5 .942 ,P= 0 .043) were the independent risk factors for BPD occurrence .The times of sputum culture positive was positively correlated with the severity of BPD(r = 0 .423 ,P< 0 .001) .The accumulative oxygen use time and mechanical ventilation time at 1 ,2 ,3 ,4 weeks had statistically significant differences between the BPD group and non‐BPD group(P< 0 .05) .The accumulative mechanical ventilation time at above time periods had statistically significant differences between the mild BPD group and severe BPD group(P < 0 .001) .Conclusion BPD is a common complication in very low birth weight infants ,usually occurs in preterm neonates with the gestational age less than 32 ;lower GA is an independent risk factor of BPD occurrence .The severity degree of pulmonary infection is correlated with BPD severity ;the infants with BPD show the oxygen dependency in the several weeks after.关键词
早产儿/极低出生体质量儿/支气管肺发育不良Key words
preterm infants/very low birth weight infants/bronchopulmonary dysplasia
