日用化学工业2016，Vol.46Issue(8)：473-478,6.DOI:10.13218/j.cnki.csdc.2016.08.010
有害结局通路指南及毒性测试应用分析
Adverse Outcome Pathways Guide and toxicity test applications
摘要
Abstract
The arising and development of Adverse Outcome Pathways (AOP)under the advocation of toxicity test vision and strategy in the 21st century as well as the pressure of regulation system changes and development of modern science and technology were reviewed. The concept and guide of AOP;the basic composition,structural conditions and information sharing of AOP as well as network and assessment of AOP were emphatically introduced. The development and application situation in two toxicity endpoints,the skin sensitization test and fish early - growth stage test were discussed as the practice instances of different AOP development strategy that is top - down approach and middle - out approach. Finally,it was concluded that the AOP relies on the development of modern science and technology as the driving force,toxicity prediction modernization as the basis,regulation mode change as the target. AOP guideline also provides an opportunity for the development of alternatives to animal testing method and testing technology innovation.关键词
有害结局通路/替代方法/毒性试验/指南/化学品Key words
Adverse Outcome Pathways/alternative method/toxicity testing/guide/chemicals分类
医药卫生引用本文复制引用
瞿小婷,程树军,秦瑶,柯逸晖..有害结局通路指南及毒性测试应用分析[J].日用化学工业,2016,46(8):473-478,6.基金项目
广东省科技计划资助项目 （）
