中国伤残医学2016，Vol.24Issue(20)：12-14,3.DOI:10.13214/j.cnki.cjotadm.2016.20.007
Sclerostin在骨折愈合期浓度的表达变化
Expression changes of Sclerostin during Human Fracture Healing
王文煜 1廖壮文 2卢志文3
作者信息
- 1. 广州市增城区仙村镇卫生院外科，广州增城 511335
- 2. 广州医科大学附属第二医院骨科
- 3. 广州市增城区新塘镇医院骨科
- 折叠
摘要
Abstract
Objective:To explore the expression changes of Sclerostin during human fracture and healing in order to intervene its expression,and provide experimental reference for promoting healing, reducing nonunion complications ,and releasing pain of the pa-tients.Methods:50 patients (aged between 18 and 70 years) with meta-/diaphyseal fractures of long bone (humerus,femur, lower leg, and forearm) and 30 healthy volunteers were enrolled in this study.All patients were followed up for 3 months after the operation.Peripheral venous blood was obtained from each patient at 1,2, 4, 6, 8 and 12 weeks after surgery,and then measure-ment of sclerostin.Statistical analyses were performed using the student T-test.Results: In the patients,the concentration of the sclerostin are 13.45 ±4.1 pmol/L (after fracture);14.76 ±7.5 pmol/L(1 week after surgery);17.31 ±5.9 pmol/L(2 weeks after surgery) ;19.56 ±8.4 pmol/L(4 weeks after surgery);17.20 ±4.1 pmol/L(6 weeks after surgery) ;21.16 ±9.1 pmol/L (8 weeks after surgery);20.23 ±7.4 pmol/L(12weeks after surgery);In the controls,the concentration of Sclerostin are fluctua-tion between7.40 ±1.2 and 7.56 ±2.5pmol/L;The comparison between the patient's SOST level and the control serum revealed significantly higher levels for the patients at all measurement time points(P <0.05)Conclusion: The concentration of Sclerostin should be strongly enhanced during human fracture healing.关键词
Sclerostin/人/骨折/愈合Key words
Sclerostin/Human/Fracture/Healing分类
医药卫生引用本文复制引用
王文煜,廖壮文,卢志文..Sclerostin在骨折愈合期浓度的表达变化[J].中国伤残医学,2016,24(20):12-14,3.
