神经病学与神经康复学杂志2016，Vol.12Issue(3)：123-130,8.DOI:10.12022/jnnr.2016-0032
急性缺血性卒中静脉溶栓治疗的疗效及预后相关因素分析
Effectiveness and prognosis-related factors of intravenous thrombolysis in patients with acute ischemic stroke
摘要
Abstract
Objective:Intravenous thrombolysis is the most effective therapy that guidelines have recommended for treating acute ischemic stroke. This study aims to evaluate the factors related to the clinical outcomes in patients with acute ischemic stroke receiving intravenous thrombolysis. Methods:This study recruited 136 patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator (rt-PA). The demography, vascular risk factors and the characteristics of acute ischemic stroke were recorded. The early improvement which was defined as complete resolution of the neurologic deficit or an improvement from baseline in the score on the National Institute of Health Stroke Scale (NIHSS) 24 hours after intravenous thrombolysis and the independent functional outcomes which was defined as a score of 0 or 1 on the modified Rankin scale (mRS) three months after the onset of stroke were evaluated. The factors related to early improvement and late independent functional outcomes were examined by univariate and multivariate analyses. Results:Sixty-six patients (48.5%) achieved early improvement and 64 patients (47.1%) achieved late independent functional outcomes. The early efficacy 2 hours, 24 hoursand7 days after intravenous thrombolysis had relevance to the later prognosis (allP < 0.05). Lower systolic pressure was independently associated with better early improvement (P < 0.05). Conclusion:Decrease in systolic blood pressure before intravenous thrombolysis may promote the early improvement in patients with acute ischemic stroke. The early response to intravenous thrombolysis may predict the late outcomes.关键词
急性缺血性卒中/静脉溶栓治疗/预后Key words
Acute ischemic stroke/Intravenous thrombolysis/Prognosis引用本文复制引用
耿介立,徐群,宋叶平,金海峰,陈莺,林岩,孙亚蒙,潘元美,俞羚,施国文..急性缺血性卒中静脉溶栓治疗的疗效及预后相关因素分析[J].神经病学与神经康复学杂志,2016,12(3):123-130,8.基金项目
上海市科学技术委员会西医引导类项目（编号14411964400）FUNDING/SUPPORT:Western Medicine Guide Project of Science and Technology Commission of Shanghai Municipality (No.1411964400) （No.1411964400）
