生物技术通报2016，Vol.32Issue(9)：23-31,9.DOI:10.13560/j.cnki.biotech.bull.1985.2016.09.004
长链非编码RAN的研究进展
Research Advances on Long Non-coding RNA
摘要
Abstract
The completion of the Human Genome Project confirmed that there is a total of 30-35 thousand coding genes,the encoding information of these genes covers only 1.5% of human 3 billion base pairs carrying the genetic information,and over 98 percent of genetic information does not directly encode the proteins. In recent years,with the rapid development of sequencing technology,it is found that genetic information of non-protein-coding genes is closely related to regulation,slicing,transcription and other biological processes. Long non-coding RNA(lncRNA)regulates the critical life processes such as epigenetic regulation,transcriptional regulation,disease control,cell differentiation,and individual development,thus it become an extremely crucial issue that how to seek the RNA functional units and predict the novel long non-coding RNA. In this review,we summarize the origin and evolution of lncRNA,the functioning in cancer biology,and some common database of lncRNA,as well as using the latest bioinformatics tools and related technologies to predict lncRNAs for further functional studies.关键词
长链非编码RNA/癌症/数据库/生物信息学Key words
lncRNA/cancer/database/bioinformatics引用本文复制引用
宋娜娜,柴志欣,钟金城..长链非编码RAN的研究进展[J].生物技术通报,2016,32(9):23-31,9.基金项目
四川省科技项目（2015JY0248），西南民族大学研究生创新型科研项目 （）
