生物技术通报2016，Vol.32Issue(9)：32-37,6.DOI:10.13560/j.cnki.biotech.bull.1985.2016.09.005
二硫键及其连接方式对防御素抗菌功能的影响研究进展
Review on Effects of Disulfide Bond and Its Connection on Antimicrobial Activity in Defensins
摘要
Abstract
Defensins are a class of endogenous,highly stable and cysteine-rich antimicrobial peptides,which play an important role in anti-microbial infection and the regulation of host immune. Six to eight conserved cysteines in the sequence form 3 to 4 pairs of disulfide bonds. The number of disulfide bond and its connection play an crucial role in maintaining the structure and antibacterial functions of defensins. In addition,mutants with high activity and low disulfide bond content also play an key role in reducing production costs and simplifying the production processes. The molecular characteristics,structure and function of defensins and their effects of redox status,number and connection mode of disulfide bonds on the antimicrobial activity are reviewed.关键词
防御素/二硫键/氧化还原/连接/抗菌活性Key words
defensin/disulfide bond/oxidation and reduction/linkage/antimicrobial activity引用本文复制引用
陈惠娴,毛若雨,滕达,王秀敏,冯兴军,王建华..二硫键及其连接方式对防御素抗菌功能的影响研究进展[J].生物技术通报,2016,32(9):32-37,6.基金项目
国家自然科学基金项目（31372346，31302004，31572444，31572445），科技支撑计划项目课题（2013BAD10B02），中国农业科学院农业科技创新工程 （）
