现代妇产科进展2016，Vol.25Issue(9)：646-650,5.DOI:10.13283/j.cnki.xdfckjz.2016.09.002
TLR3、NF-κB和IL-1β在宫颈上皮内瘤变及宫颈癌中的表达及意义
Expression and clinical significance of TLR3、NF-κB and IL-1βin cervical lesions. Zhang Qian,Zhang Shulan
摘要
Abstract
Objective:To detect the expression of TLR3,NF-κB and IL-1β in the cer-vical intraepithelial neoplasia(CIN) and cervical squamous cell carcinoma,to investigate the relationship among them and the relationship with clinicopathological parameters. Methods:120 cases of gynecologic surgery specimen were collected in Shengjing Hospital of China Medical U-niversity between Jan. 2014 and Dec. 2014,including 60 cases of cervical squamous cell carci-noma,40 cases of CIN and 20 cases of normal cervical tissue. The expression of TLR3,NF-κB and IL-1β was detected using immunohistochemical methods. Results:The positive expression rates of TLR3 were 100%,75%,23. 23% respectively in normal cervix, CIN, and cervical squamous cell carcinoma. The positive expression rates of NF-κB and IL-1β were 0%,60%, 90% and 0%,70%,90%. The differences among these groups were statistically significant( P<0 . 005 ) . The expression of TLR3 was associated with clinical stage in cervical squamous cell carcinoma(P<0. 05). The expression of NF-κB and IL-1β was associated with clinical stage, pathological grading and lymph node metastasis(P<0. 05). There was no significant relationship between the expression and patients'age (P>0. 05). There was significantly negative correlation between the expression of TLR3 and NF-κB, IL-1β( rs=-0. 478, P<0. 01;rs=-0. 45, P<0. 01). There was significantly positive correlation between NF-κB and IL-1β(rs=0. 589,P<0. 01). Conclusion:The expression of TLR3 decreased in cervical cancer,while the expression of NF-κB and IL-1βincreased. It could provide certain theory basis for the TLR agonists to treat cervical cancer.关键词
宫颈癌/宫颈上皮内瘤变/Toll样受体3/核转录因子-κB/白细胞介素-1βKey words
Cervical cancer/CIN/TLR3/NF-κB/IL-1β分类
医药卫生引用本文复制引用
张倩,张淑兰..TLR3、NF-κB和IL-1β在宫颈上皮内瘤变及宫颈癌中的表达及意义[J].现代妇产科进展,2016,25(9):646-650,5.基金项目
盛京自由者(No:201302) （No:201302）
