现代妇产科进展2016，Vol.25Issue(9)：654-657,4.DOI:10.13283/j.cnki.xdfckjz.2016.09.004
术前外周血淋巴细胞/单核细胞比值与上皮性卵巢癌患者预后的关系
The relationship between preoperative blood lymphocyte-to-monocyte ratio and the prog-nostic of epithelial ovarian cancer
摘要
Abstract
Objective:To measure the prognostic value of the lymphocyte to monocyte ratio( LMR) in patients with epithelial ovarian cancer( EOC) . Methods:A retrospective cohort of 240 patients who were newly diagnosed EOC and underwent surgical resection was recruited between Jan. 2000 and Dec. 2013,which collected from the First Affiliated Hospital of Zheng-zhou University. Patients were categorized into two different groups based on the LMR,LMR-low (≤3 . 949 ) and LMR-high (>3 . 949 ) , using cut-off values determined by receiver operating characteristic( ROC) curve analysis. The clinicopathological characteristics and survivals be-tween the two groups were compared by Log-Rank Test. Multivariate COX proportional hazards analyses were applied to validate the LMR as an independent predictor of survival. Results:U-sing the data collected from the whole cohort,the optimized LMR cut-off value selected on the ROC curve was 3. 949 for the OS. The pretreatment LMR differed significantly in the Interna-tional Federation of Gynecology and Obstetrics ( FIGO) stage,CA-125 level and Lactate dehy-drogenase(LDH)level between the low LMR group and the high LMR group(P=0. 000,P=0. 000,and P=0. 002,respectively),while no discrimination was observed in other parameters.Univariate analysis revealed that age(>56),LMR≤3. 949,FIGO III ~IV,pathological type (mucinous carcinoma)and advanced tumor stage were associated with poor OS(P=0. 003,P=0. 013,P=0. 001,P=0. 002 and P=0. 028,respectively). On multivariate analysis,we identi-fied FIGO stage and the LMR as a significantly independent predictor for OS. Conclusion:The reduced pretreatment peripheral LMR level indicates poor prognosis in patients with EOC and may function as an important independent prognostic factor affecting the survival of patients with EOC.关键词
上皮性卵巢癌/淋巴细胞/单核细胞比值/预后Key words
Epithelial ovarian cancer/Lymphocyte-to-Monocyte Ratio/Prognosis分类
医药卫生引用本文复制引用
王秀娟,苑中甫,邱海峰,张瑞涛,丁璐璐,赵攀攀,张亚娟,刘传娜..术前外周血淋巴细胞/单核细胞比值与上皮性卵巢癌患者预后的关系[J].现代妇产科进展,2016,25(9):654-657,4.基金项目
国家自然科学基金资助项目(No:81502261) （No:81502261）
