现代妇产科进展2016，Vol.25Issue(9)：658-660,3.DOI:10.13283/j.cnki.xdfckjz.2016.09.038
卵巢肿瘤患者尿液中miRNA-200 c-3 p的表达及意义
Urine miRNA-200 c-3 p as potential diagnostic biomarkers for ovarian tumor
田雨子 1孙金剑 1吴帆 1陈晓宇 1张路远 1杨美婵 1吴晓英1
作者信息
- 1. 中南大学基础医学院病理学系，长沙 410013
- 折叠
摘要
Abstract
Objective:To evaluate the diagnostic significance of urine miRNA-200 c-3 p in ovarian tumor by measuring its different expression levels. Method:Urine was collected from 14 patients with ovarian tumor, including 8 benign ovarian tumors and 6 malignant ovarian tumors,and 6 healthy controls. The relative expression levels of miRNA-200c-3p were measured by quantificational real-time polymerase chain reaction assay ( qRT-PCR) . Results:The expres-sion levels of miRNA-200 c-3 p was significantly increased in ovarian tumor group than that of healthy group(P<0. 05). While we found no statistical significant among the malignant tumors, benign tumors and healthy controls by one-way analysis of variance(P=0. 062). The AUC (ar-ea under the curve) of ROC curve was 0. 821. The sensitivity and specificity of miRNA-200c-3p for diagnosing ovarian tumor were 63. 7% and 86. 7% respectively. Conclusion:miRNA-200c-3p can potentially serve as a biomarker for ovarian tumor detection.关键词
microRNA/卵巢肿瘤/尿液/生物标志物Key words
microRNA/Ovarian tumor/Urine/Biomarker分类
医药卫生引用本文复制引用
田雨子,孙金剑,吴帆,陈晓宇,张路远,杨美婵,吴晓英..卵巢肿瘤患者尿液中miRNA-200 c-3 p的表达及意义[J].现代妇产科进展,2016,25(9):658-660,3.
