李辉 1吴栋文 2单年春 3曹兰 3王永刚 1刘婧 2李艳萍1
作者信息
- 1. 中南大学湘雅医院生殖中心，长沙 410012
- 2. 中南大学湘雅医学院，长沙 410012
- 3. 中南大学湘雅医院妇产科，长沙 410012
- 折叠
摘要
Abstract
Objective:To assess the efficacy and safety of radiotherapy and chemora-diotherapy combined with sodium glycididazole ( CMNa) in treating cervical cancer by conduc-ting a meta-analysis. Methods:Collect randomized clinical controlled studies ( RCTs) of radio-therapy or chemoradiotherapy plus sodium glysididazole ( CMNa ) versus control group without CMNa in the treatment of cervical cancer,which were retrieved from Chinese Biomedical Data-base,Chinese periodical full text database ( CNKI ) , Wan-fang database, Database of Chinese Periodicals of Science and Technology, PubMed, Cochrane Library and Embase. According to the inclusion and exclusion criteria,data extraction and quality assessment were done by two re-searchers independently,and clinically important measures were selected. Outcomes were pooled with Revman5. 3 and Stata 13. 0. Results:The complete remission(CR) rate of the combined sodium glysididazole group was better than that of the control ( OR=3. 77,95%CI=2. 60 ~5. 47,P<0. 001;radiotherapy subgroup:OR=6. 01,95%CI=3. 26~11. 08,P<0. 001;chemo-radiotherapy subgroup:OR=2. 72,95%CI=1. 69 ~4. 40,P<0. 001). The dose needed to a-chieve CR was lower in combined sodium glysididazole group(SMD=-1. 84,95%CI=-2. 47~-1. 20,P<0. 001;radiotherapy subgroup:SMD=-1. 54,95%CI= -2. 02~-1. 06,P<0. 001;chemoradiotherapy subgroup:SMD=-2. 71,95%CI为-3. 54~-1. 88,P<0. 001). There were no significant differences in the incidence rates of gastrointestinal adverse reaction,myelosup-pression,radioactive enteritis, radiocystitis and adverse reaction of skin and mucosa. Conclu-sion:In the treatments of cervical cancer,the CR in radiotherapy and chemoradiotherapy com-bined with sodium glysididazole group are superior to radiotherapy or chemoradiotherapy alone group and less radiation dose is needed. And,the occurrence rates of adverse reactions in the two groups have no obvious differences and the safety is identified.关键词
宫颈癌/放射疗法/同步放化疗/甘氨双唑钠/Meta分析Key words
Cervical cancer/Radiotherapy/Chemoradiotherapy/Sodium glysididazole ( CMNa)/Meta-analysis分类
医药卫生
