中国组织工程研究2016，Vol.20Issue(37)：5594-5601,8.DOI:10.3969/j.issn.2095-4344.2016.37.018
细胞因子对骨骼肌细胞和胰岛β细胞的作用
Effects of cytokines on skeletal muscle cells and pancreatic beta cells
摘要
Abstract
BACKGROUND:A variety of cytokines such as cytokines, growth factors and inflammatory proteins play an important role in the development of skeletal muscle. <br> OBJECTIVE:To investigate the biological characteristics of a variety of cytokines and their effects on skeletal muscle cel s and pancreaticβcel s. <br> METHODS:Relevant articles published from 2002 to 2015 were retrieved in CNKI and PubMed databases using the English keywords“cytokines, adiponectin, leptin, visfatin, skeletal muscle cel s, pancreaticβcel s”. Initial y 253 literatures were obtained, and final y 53 eligible literatures were included based on the exclusion criteria. <br> RESULTS AND CONCLUSION:As a fat-specific protein newly found, adiponectin can improve the insulin sensitivity by promoting glucose uptake, storage and utilization in skeletal muscle cel s. The activation of muscle satel ite cel s and skeletal myoblast proliferation are both dependent on leptin, so leptin plays a vital role in the skeletal muscle cel growth and development. Visfatin, a pleiotropic cytokine, widely presents in the skeletal muscle, liver and bone marrow, and participates in the regulation of inflammation and immune function. Furthermore, visfatin contributes to glucose uptake and metabolism in the skeletal muscle, and makes considerable effects on the stress and signal transduction of skeletal muscle cel s.关键词
组织构建/组织工程/细胞因子/骨骼肌/细胞/胰岛β细胞分类
医药卫生引用本文复制引用
李靖,张翔,王丽萍,石磊,牟宇政,常茜茜..细胞因子对骨骼肌细胞和胰岛β细胞的作用[J].中国组织工程研究,2016,20(37):5594-5601,8.基金项目
山西省2014年大学生创业创新训练基金项目，课题名称减肥物质结合运动减肥效用研究；山西省忻州师范学院重点建设学科专项课题项目(xk201403)Funding:the Shanxi Provincial Foundation for Col ege Students Entrepreneurship Innovation Training in 2014 （xk201403）
the Key Construction Disciplines Project of Xinzhou Teachers University in Shanxi Province, No. xk201403 （）
