中国组织工程研究2016，Vol.20Issue(38)：5691-5696,6.DOI:10.3969/j.issn.2095-4344.2016.38.010
局部定向抗结核药物缓释材料在兔桡骨内的释放及分布规律
Release and distribution of anti-tuberculosis drug delivery materials locally oriented in the rabbit radius
摘要
Abstract
BACKGROUND:Polylactic acid-glycolic acid polymer is a sustained-release material with relatively large drug loading and long-term release abilities that can degrade with cel growth in the body. However, its poor hydrophily easily leads to aseptic inflammation that is detrimental to the body’s recovery. OBJECTIVE:To study the release and distribution of anti-tuberculosis drug delivery materials local y oriented within the rabbit radius. METHODS:After modeling, 20 New Zealand white rabbits with distal radius bone defect were randomly divided into a control group and an experimental group, which were respectively given implantation of isoniazid-rifampicin polylactic acid-glycolic acid polymer/β-tricalcium phosphate material and isoniazid-rifampicin polylactic acid-glycolic acid polymer into the defect. Then, X-ray examination of the defect region was conducted at weeks 4, 8, 12 post implantation. Histological observation and detection of peripheral blood or local blood concentration were performed at week 12. RESULTS AND CONCLUSION:After implantation, Lane-Sandhu X-ray scores were significantly higher in the experimental group than the control group (P<0.05). The defect in the experimental group was healed completely with less release residual among newborn bone trabeculae and osteocytes were markedly visible on the material surface, while in the control group, new bone tissues were interconnected with the surrounding bone tissues at the defect site, and less release residual was found. Both peripheral blood and local blood concentrations in the experimental group were significantly higher than those in the control group after implantation (P<0.05). To conclude, the anti-tuberculosis drug delivery material, isoniazid-rifampicin polylactic acid-glycolic acid polymer/β-tricalcium phosphate, has ideal release effect that can stably deliver anti-tuberculosis drugs for a long term at a high bactericidal concentration.关键词
生物材料/缓释材料/局部定向/抗结核药物/分布规律/骨缺损/聚乳酸-羟基乙酸聚合物/利福平/异烟肼分类
医药卫生引用本文复制引用
苗瑞瑞,张文龙,鲍玉成,李梅..局部定向抗结核药物缓释材料在兔桡骨内的释放及分布规律[J].中国组织工程研究,2016,20(38):5691-5696,6.基金项目
天津市卫生局课题(2010KY10) （2010KY10）
